Effectiveness of matching human leukocyte antigens
Effectiveness of matching human leukocyte antigens (HLA) in corneal transplantation: a scientific overview protocol
Background: Corneal transplantation is probably the most steadily carried out transplantation within the UK. Regardless of this, the therapeutic worth of matching human leukocyte antigen (HLA) subtypes for transplanted corneas stays controversial. Ocular immune privilege was initially deemed to render matching pointless; nevertheless, extra lately, matching has demonstrated improved outcomes together with graft success, amongst others. This systematic overview goals to guage the effectiveness of main and minor antigen matching on graft outcomes in corneal transplantation.
Strategies: Normal systematic overview methodology can be used to determine, choose and extract knowledge from observational research and medical trials assessing the results of HLA matching on corneal graft outcomes. Bibliographic databases (Cochrane Library, EMBASE, MEDLINE, Net of Science, Scopus), medical trial registers, summary and convention proceedings, along with dissertation, thesis and gray literature can be searched. Neither date of publication nor language can be restricted, and non-English articles can be translated the place obligatory. The first end result can be to evaluate corneal graft success for various levels of HLA matching/mismatching.
The exact finish end result measure varies amongst research and contains graft rejection, immunoreaction, failure and survival. Subsequently, knowledge can be extracted throughout all related end result parameters and grouped for subsequent statistical exams. Danger of bias evaluation can be accomplished, acceptable to every examine design. Research choice, knowledge extraction and threat of bias evaluation can be independently accomplished by two reviewers. Knowledge can be tabulated, and a story synthesis introduced. Meta-analysis can be carried out the place there may be ample homogeneity between research to warrant its efficient completion. Subgroup and sensitivity evaluation can be undertaken if acceptable.
Dialogue: Many research have investigated the effectiveness of HLA matching for corneal transplantation. A scientific overview is required to collate and analyse this proof. Findings of this systematic overview might kind the premise of evidence-based suggestions on pre-operative HLA typing and matching of corneal grafts for transplantation.
 Rat Scl-70 Ab ELISA Kit |
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| ERS0249 | Abclonal | 96Tests | EUR 521 |
 Canine Scl-70 Ab ELISA Kit |
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| ECS0249 | Abclonal | 96Tests | EUR 521 |
 Bovine Scl-70 Ab ELISA Kit |
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| EBS0249 | Abclonal | 96Tests | EUR 521 |
 Goat Scl-70 Ab ELISA Kit |
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| EGTS0249 | Abclonal | 96Tests | EUR 521 |
 Human Scl-70 Ab ELISA Kit |
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| EHS0249 | Abclonal | 96Tests | EUR 521 |
 Anserini Scl-70 Ab ELISA Kit |
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| EAS0249 | Abclonal | 96Tests | EUR 521 |
 Monoclonal Anti-Human Scl-70 IgG |
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| SCL701-M | Alpha Diagnostics | 100 ul | EUR 482 |
 Guinea Pig Scl-70 Ab ELISA Kit |
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| EGS0249 | Abclonal | 96Tests | EUR 521 |
 Antibody) DNA Topoisomerase I (TOP1, Scl-70) Antibody |
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| 30267-05111 | AssayPro | 150 ug | EUR 261 |
 Dog Anti SCL 70 antibody ELISA kit |
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| E08S0243-192T | BlueGene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Canine Anti SCL 70 antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Dog Anti SCL 70 antibody ELISA kit |
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| E08S0243-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Canine Anti SCL 70 antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Dog Anti SCL 70 antibody ELISA kit |
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| E08S0243-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Canine Anti SCL 70 antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 Rabbit Anti SCL 70 antibody ELISA kit |
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| E04S0243-192T | BlueGene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Rabbit Anti SCL 70 antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rabbit Anti SCL 70 antibody ELISA kit |
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| E04S0243-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Rabbit Anti SCL 70 antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rabbit Anti SCL 70 antibody ELISA kit |
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| E04S0243-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Rabbit Anti SCL 70 antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 Goat Anti SCL 70 antibody ELISA kit |
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| E06S0243-192T | BlueGene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Goat Anti SCL 70 antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Goat Anti SCL 70 antibody ELISA kit |
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| E06S0243-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Goat Anti SCL 70 antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Goat Anti SCL 70 antibody ELISA kit |
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| E06S0243-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Goat Anti SCL 70 antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 Human Anti SCL 70 antibody ELISA kit |
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| E01S0243-192T | BlueGene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Human Anti SCL 70 antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human Anti SCL 70 antibody ELISA kit |
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| E01S0243-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Human Anti SCL 70 antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human Anti SCL 70 antibody ELISA kit |
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| E01S0243-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Human Anti SCL 70 antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 Mouse Anti SCL 70 antibody ELISA kit |
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| E03S0243-192T | BlueGene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Mouse Anti SCL 70 antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Anti SCL 70 antibody ELISA kit |
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| E03S0243-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Mouse Anti SCL 70 antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Anti SCL 70 antibody ELISA kit |
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| E03S0243-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Mouse Anti SCL 70 antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 Pig Anti SCL 70 antibody ELISA kit |
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| E07S0243-192T | BlueGene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Porcine Anti SCL 70 antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Pig Anti SCL 70 antibody ELISA kit |
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| E07S0243-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Porcine Anti SCL 70 antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Pig Anti SCL 70 antibody ELISA kit |
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| E07S0243-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Porcine Anti SCL 70 antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 Rat Anti SCL 70 antibody ELISA kit |
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| E02S0243-192T | BlueGene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Rat Anti SCL 70 antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Anti SCL 70 antibody ELISA kit |
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| E02S0243-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Rat Anti SCL 70 antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Anti SCL 70 antibody ELISA kit |
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| E02S0243-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Rat Anti SCL 70 antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 Monkey Anti SCL 70 antibody ELISA kit |
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| E09S0243-192T | BlueGene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Monkey Anti SCL 70 antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Monkey Anti SCL 70 antibody ELISA kit |
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| E09S0243-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Monkey Anti SCL 70 antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Monkey Anti SCL 70 antibody ELISA kit |
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| E09S0243-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Monkey Anti SCL 70 antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 Guinea pig Anti SCL 70 antibody ELISA kit |
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| E05S0243-192T | BlueGene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Guinea pig Anti SCL 70 antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Guinea pig Anti SCL 70 antibody ELISA kit |
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| E05S0243-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Guinea pig Anti SCL 70 antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Guinea pig Anti SCL 70 antibody ELISA kit |
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| E05S0243-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Guinea pig Anti SCL 70 antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 DiagNano Fluorophore Labeled Gold Nanoparticles, 70 nm |
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| GFL-70 | Creative Diagnostics | 1 mL | EUR 1053 |
) Custom Peptide Synthesis (>70% antigen grade; mass spec, hplc (mg-kg size, price based upon peptide size: 2-100 aa) |
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| PEP-70 | Alpha Diagnostics | 1 | Ask for price |
) Human Scl-70 Autoantibody IgG ELISA Kit (Direct EIA) |
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| EK7087 | BosterBio | 96wells/kit, with removable strips. | EUR 478 |
 Antibody (Biotin Conjugate)) DNA Topoisomerase I (TOP1, Scl-70) Antibody (Biotin Conjugate) |
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| 30267-05121 | AssayPro | 150 ug | EUR 369 |
 Human Scl-70 protein WB +ve control) Recombinant (sf9) Human Scl-70 protein WB +ve control |
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| SCL701-C | Alpha Diagnostics | 100 ul | EUR 286 |
 Human Scl-70 protein (>95%, His-tag)) Recombinant (sf9) Human Scl-70 protein (>95%, His-tag) |
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| SCL702-R-10 | Alpha Diagnostics | 10 ug | EUR 286 |
 DiagNano Gold Nanoparticle Passive Conjugation Kit, 70 nm |
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| GPK-70 | Creative Diagnostics | 1 kit | EUR 715 |
 Native ScI-70 Antigen |
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| DAGA-3028 | Creative Diagnostics | 1000 UNITS | EUR 2015 |
 AssayLite Antibody (FITC Conjugate)) DNA Topoisomerase I (TOP1, Scl-70) AssayLite Antibody (FITC Conjugate) |
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| 30267-05141 | AssayPro | 150 ug | EUR 428 |
 AssayLite Antibody (RPE Conjugate)) DNA Topoisomerase I (TOP1, Scl-70) AssayLite Antibody (RPE Conjugate) |
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| 30267-05151 | AssayPro | 150 ug | EUR 428 |
 AssayLite Antibody (APC Conjugate)) DNA Topoisomerase I (TOP1, Scl-70) AssayLite Antibody (APC Conjugate) |
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| 30267-05161 | AssayPro | 150 ug | EUR 428 |
 AssayLite Antibody (PerCP Conjugate)) DNA Topoisomerase I (TOP1, Scl-70) AssayLite Antibody (PerCP Conjugate) |
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| 30267-05171 | AssayPro | 150 ug | EUR 471 |
) Bacillus anthracis antibody (Protective Antigen) |
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| 70-1007 | Fitzgerald | 1 mg | EUR 367 |
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Description: Polyclonal Bacillus anthracis antibody (Protective Antigen), Anti-Bacillus anthracis antibody (Protective Antigen), Bacillus anthracis PA antibody, Anthrax PA antibody, Bacillus anthracis Protective Antigen antibody, Anthrax Protective Antigen antibody |
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 IgG negative control serum/plasma) Human Anti-Scl-70 (Scl70/Scleroderma 70 Kda/DNA-topoisomerase-1) IgG negative control serum/plasma |
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| 3300-140-N01 | Alpha Diagnostics | 1 ml | EUR 164 |
 IgG positive control serum/plasma) Human Anti-Scl-70 (Scl70/Scleroderma 70 Kda/DNA-topoisomerase-1) IgG positive control serum/plasma |
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| 3300-140-P02 | Alpha Diagnostics | 1 ml | EUR 225 |
 DiagNano Gold Nanoparticle Medium Covalent Conjugation Kit, 70 nm |
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| GCK-M-70 | Creative Diagnostics | 1 kit | EUR 757 |
 IgG ELISA kit, 96 tests, Quantitative) Human Anti-Scl-70 (Scl70/Scleroderma 70 Kda/DNA-topoisomerase-1) IgG ELISA kit, 96 tests, Quantitative |
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| 3300-140-SCG | Alpha Diagnostics | 1 Kit | EUR 590 |
 CTLD scaffold protein anti-Human DR4 |
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| SCl-L066 | Creative Biolabs | 1 mg | EUR 4496 |
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Description: Scaffold protein |
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 CTLD scaffold protein anti-Human DR5 |
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| SCl-L067 | Creative Biolabs | 1 mg | EUR 4496 |
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Description: Scaffold protein |
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 Antibody) Positive Control Set (SS-A, SS-B, Sm, RNP, Scl-70, Jo-1) Antibody |
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| abx022694-1Set | Abbexa | 1 Set | EUR 1414 |
 Recombinant Human PM/Scl 100 |
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| RP-887 | Alpha Diagnostics | 5 ug | EUR 164 |
 TAL1 / SCL LS-C182473 Antibody |
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| 48340-100ul | SAB | 100ul | EUR 333 |
TAL1 / SCL LS-C182473 Antibody |
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| 48340-50ul | SAB | 50ul | EUR 239 |
 Protein ELISA Kit, 96 tests, Quantitative) Human Erythropoietin (EPO) Protein ELISA Kit, 96 tests, Quantitative |
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| 70 | Alpha Diagnostics | 1 kit | EUR 773 |
) Recombinant Plasmodium Falciparum PPF2L antigen Protein (aa 1-70) |
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| VAng-Wyb6754-1mgBaculovirus | Creative Biolabs | 1 mg (Baculovirus) | EUR 6993 |
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Description: Plasmodium Falciparum (isolate Palo Alto / Uganda) PPF2L antigen, recombinant protein. |
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Recombinant Plasmodium Falciparum PPF2L antigen Protein (aa 1-70) |
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| VAng-Wyb6754-500gBaculovirus | Creative Biolabs | 500 µg (Baculovirus) | EUR 4490 |
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Description: Plasmodium Falciparum (isolate Palo Alto / Uganda) PPF2L antigen, recombinant protein. |
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Recombinant Plasmodium Falciparum PPF2L antigen Protein (aa 1-70) |
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| VAng-Wyb6754-50gBaculovirus | Creative Biolabs | 50 µg (Baculovirus) | EUR 2401 |
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Description: Plasmodium Falciparum (isolate Palo Alto / Uganda) PPF2L antigen, recombinant protein. |
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 Sheep Anti-PM-Scl ELISA Kit |
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| ESP0698 | Abclonal | 96Tests | EUR 521 |
 Rabbit Anti-PM-Scl ELISA Kit |
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| ERTP0698 | Abclonal | 96Tests | EUR 521 |
 Monkey Anti-PM-Scl ELISA Kit |
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| EMKP0698 | Abclonal | 96Tests | EUR 521 |
 Mouse Anti-PM-Scl ELISA Kit |
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| EMP0698 | Abclonal | 96Tests | EUR 521 |
 Porcine Anti-PM-Scl ELISA Kit |
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| EPP0698 | Abclonal | 96Tests | EUR 521 |
 Rat Anti-PM-Scl ELISA Kit |
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| ERP0698 | Abclonal | 96Tests | EUR 521 |
 Bovine Anti-PM-Scl ELISA Kit |
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| EBP0698 | Abclonal | 96Tests | EUR 521 |
 Chicken Anti-PM-Scl ELISA Kit |
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| ECKP0698 | Abclonal | 96Tests | EUR 521 |
 Canine Anti-PM-Scl ELISA Kit |
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| ECP0698 | Abclonal | 96Tests | EUR 521 |
 Goat Anti-PM-Scl ELISA Kit |
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| EGTP0698 | Abclonal | 96Tests | EUR 521 |
 Human Anti-PM-Scl ELISA Kit |
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| EHP0698 | Abclonal | 96Tests | EUR 521 |
 Antibody) SCL-Interrupting Locus Protein (STIL) Antibody |
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| 20-abx126666 | Abbexa |
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SCL-Interrupting Locus Protein (STIL) Antibody |
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| 20-abx313345 | Abbexa |
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SCL-Interrupting Locus Protein (STIL) Antibody |
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| abx145676-100ug | Abbexa | 100 ug | EUR 391 |
 TAL1 / SCL LS-C182473 Conjugated Antibody |
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| C48340 | SAB | 100ul | EUR 397 |
 Guinea Pig Anti-PM-Scl ELISA Kit |
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| EGP0698 | Abclonal | 96Tests | EUR 521 |
 Anserine PM-Scl/PM-1 ELISA Kit |
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| EAP0698 | Abclonal | 96Tests | EUR 521 |
 Antibody (HRP)) SCL-Interrupting Locus Protein (STIL) Antibody (HRP) |
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| 20-abx313346 | Abbexa |
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 Antibody (FITC)) SCL-Interrupting Locus Protein (STIL) Antibody (FITC) |
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| 20-abx313347 | Abbexa |
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 Antibody (Biotin)) SCL-Interrupting Locus Protein (STIL) Antibody (Biotin) |
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| 20-abx313348 | Abbexa |
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 Ficoll 70 |
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| FT1159 | Bio Basic | 25g | EUR 102.2 |
 WWL 70 |
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| A8891-10 | ApexBio | 10 mg | EUR 189 |
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Description: WWL 70 is a potent inhibitor of ?/?-hydrolase domain 6 (ABHD6) with IC50 value of 70 nM [1].WWL 70 is an O-aryl group-modified derivative of carbamate 18 which is a lead inhibitor of ABHD6 screened out by a functional proteomic strategy. |
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WWL 70 |
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| A8891-2000 | ApexBio | 2000 mg | EUR 7590 |
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Description: WWL 70 is a potent inhibitor of ?/?-hydrolase domain 6 (ABHD6) with IC50 value of 70 nM [1].WWL 70 is an O-aryl group-modified derivative of carbamate 18 which is a lead inhibitor of ABHD6 screened out by a functional proteomic strategy. |
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WWL 70 |
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| A8891-5 | ApexBio | 5 mg | EUR 142 |
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Description: WWL 70 is a potent inhibitor of ?/?-hydrolase domain 6 (ABHD6) with IC50 value of 70 nM [1].WWL 70 is an O-aryl group-modified derivative of carbamate 18 which is a lead inhibitor of ABHD6 screened out by a functional proteomic strategy. |
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WWL 70 |
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| A8891-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 177 |
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Description: WWL 70 is a potent inhibitor of ?/?-hydrolase domain 6 (ABHD6) with IC50 value of 70 nM [1].WWL 70 is an O-aryl group-modified derivative of carbamate 18 which is a lead inhibitor of ABHD6 screened out by a functional proteomic strategy. |
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WWL 70 |
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| A8891-50 | ApexBio | 50 mg | EUR 606 |
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Description: WWL 70 is a potent inhibitor of ?/?-hydrolase domain 6 (ABHD6) with IC50 value of 70 nM [1].WWL 70 is an O-aryl group-modified derivative of carbamate 18 which is a lead inhibitor of ABHD6 screened out by a functional proteomic strategy. |
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 Monoclonal Antibody) Mouse Anti-Hepatitis B Core Antigen (a.a. 70-80) Monoclonal Antibody |
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| DMAB3506 | Creative Diagnostics | 0.1 mg | EUR 689 |
 Human SCL- interrupting locus protein, STIL ELISA KIT |
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| ELI-29893h | Lifescience Market | 96 Tests | EUR 824 |
 Monoclonal Antibody) Mouse Anti-Hepatitis C Virus Core Antigen (a.a. 70-90) Monoclonal Antibody |
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| DMAB3561 | Creative Diagnostics | 0.1 mg | EUR 781 |
CD4 + T Cells of Prostate Most cancers Sufferers Have Decreased Immune Responses to Antigens Derived From SARS-CoV-2 Spike Glycoprotein
The adaptive immune response to extreme acute respiratory coronavirus 2 (SARS-CoV-2) is essential for vaccine growth and within the restoration from coronavirus illness 2019 (COVID-19). Males and most cancers sufferers have been reported to be at greater dangers of contracting the virus and creating the extra extreme types of COVID-19. Prostate most cancers (PCa) could also be related to each of those dangers. We present that CD4+ T cells of SARS-CoV-2-unexposed sufferers with hormone-refractory (HR) metastatic PCa had decreased CD4+ T cell immune responses to antigens from SARS-CoV-2 spike glycoprotein however not from the spiked glycoprotein of the ‘frequent chilly’-associated human coronavirus 229E (HCoV-229E) as in contrast with wholesome male volunteers who responded comparably to each HCoV-229E- and SARS-CoV-2-derived antigens.
Furthermore, the HCoV-229E spike glycoprotein antigen-elicited CD4+ T cell immune responses cross-reacted with the SARS-CoV-2 spiked glycoprotein antigens. PCa sufferers might have impaired responses to the vaccination, and the cross-reactivity can mediate antibody-dependent enhancement (ADE) of COVID-19. These findings spotlight the potential for elevated vulnerability of PCa sufferers to COVID-19.
Circulating SARS-CoV-2 Vaccine Antigen Detected within the Plasma of mRNA-1273 Vaccine Recipients
SARS-CoV-2 proteins had been measured in longitudinal plasma samples collected from 13 individuals who obtained two doses of mRNA-1273 vaccine. 11 of 13 individuals confirmed detectable ranges of SARS-CoV-2 protein as early as day one after first vaccine injection. Clearance of detectable SARS-CoV-2 protein correlated with manufacturing of IgG and IgA.
Characterizing Prostate-Particular Antigen Ranges at Dying in Sufferers with Metastatic Castration-Resistant Prostate Most cancers: Are We Underutilizing Imaging?
Background: Prostate-specific antigen (PSA) is a beneficial prognostic and predictive biomarker in prostate most cancers; nevertheless, the importance of PSA at or close to the time of demise isn’t properly understood. This examine aimed to characterize the importance of PSA at demise in sufferers with metastatic castration-resistant prostate most cancers (mCRPC).
Sufferers and strategies: The Mount Sinai Genitourinary Most cancers Biorepository, an institutional overview board-approved, single-institution database containing all consented genitourinary most cancers sufferers seen between 2010 and 2018, was used to determine and stratify sufferers into the next cohorts based mostly on their PSA at or close to demise: <100 ng/mL, 100-1000 ng/mL, and >1000 ng/mL. Analyses had been carried out to evaluate medical traits of illness, remedy response, and outcomes.
Outcomes: We recognized 1097 sufferers with prostate most cancers, and 101 had been confirmed to be deceased following a prognosis of mCRPC. In sufferers with mCRPC, cohorts of upper PSA degree at demise had been related to decrease Gleason rating at prognosis and a pattern towards longer time to mCRPC and longer time from prognosis to demise, regardless of the next burden of illness at demise. Conversely, subgroup evaluation of PSA < 10 ng/mL at demise was related to decrease charges of imaging inside 6 months of demise, decrease remedy charge, and worse medical outcomes.
Conclusions: Cohorts of various PSA ranges at demise in mCRPC sufferers confirmed distinct patterns of illness traits and medical outcomes, possible as a result of underlying molecular phenotype variations. Imaging for the affected person inhabitants with very low PSA ranges could also be underutilized and needs to be thought-about extra routinely.
Actual-world medical efficiency of economic SARS-CoV-2 speedy antigen exams in suspected COVID-19: A scientific meta-analysis of obtainable knowledge as per November 20, 2020
Goals: Speedy antigen exams, or RATs, are a sort of lateral move chromatographic immunoassay which have been utilized to assist prognosis of SARS-CoV-2 an infection. We carried out a scientific meta-analysis to check the real-world efficiency of commercially obtainable RATs.
Strategies: We searched a number of databases and web sites for manufacturer-independent potential medical efficiency research evaluating SARS-CoV-2 RATs and RT-PCR. Solely research on RATs that didn’t want a separate reader for end result retrieval and that reported knowledge on viral load, sufferers’ symptom standing, pattern kind, and PCR assay used had been included.
Outcomes: 19 research using 11,109 samples with 2,509 RT-PCR-positives had been included. RAT sensitivity various between 28.9% (95% CI 16.4-44.3) and 98.3% (95% CI 91.1-99.7), possible dependent upon inhabitants traits, viral load, and symptom standing. RAT specificity various between 92.4% (95% CI 87.4-95.9) and 100% (95% CI 99.7-100) with one outlier. The RATs by Roche Diagnostics/SD Biosensor and Abbott had the very best pooled sensitivity (82.4% [95% CI 74.2-88.4] and 76.9% [95% CI 72.1-81.2], respectively). Sensitivity in high-viral-load samples (cycle threshold ≤25) confirmed heterogeneity among the many totally different RATs.
Conclusion: The RATs provided by Roche Diagnostics/SD Biosensor and Abbott present ample manufacturer-independent, real-world efficiency knowledge to help their use for detection of present SARS-CoV-2 an infection, notably in high-viral-load populations.
