• May 25, 2021
formulapharma

Integrating Prostate-specific Antigen Kinetics into Contemporary

Integrating Prostate-specific Antigen Kinetics into Up to date Predictive Nomograms of Salvage Radiotherapy After Radical Prostatectomy

Background: Salvage radiotherapy (SRT) is a longtime remedy for males with biochemical recurrence following radical prostatectomy (RP). There are a number of danger elements related to antagonistic outcomes; nevertheless, the worth of postoperative prostate-specific antigen (PSA) kinetics is much less clear within the ultrasensitive PSA period.

Goal: To characterize the impression of PSA kinetics on outcomes following SRT and generate nomograms to help in figuring out sufferers with an elevated danger of antagonistic scientific outcomes.

Design, setting, and individuals: A multi-institutional evaluation was carried out of 1005 sufferers with prostate most cancers handled with SRT after RP, with a median follow-up of 5 years.

Final result measurements and statistical evaluation: Variables examined embrace instant postoperative PSA, postoperative PSA doubling time (DT), and pre-SRT PSA, along with beforehand recognized predictive elements. Multivariable survival analyses have been accomplished utilizing High quality-Grey competing danger regression. Charges of biochemical failure (BF), distant metastasis (DM), and prostate cancer-specific mortality (PCSM) have been estimated by the cumulative incidence methodology. Nomograms have been generated from multivariable competing danger regression with bootstrap cross-validation.

Outcomes and limitations: Elements related to BF after SRT embrace PSA DT <6 mo, preliminary postoperative PSA ≥0.2 ng/ml, greater pre-SRT PSA, lack of androgen deprivation remedy, a better Gleason rating (GS), detrimental margins, seminal vesicle invasion, lack of pelvic nodal radiation, radiation complete dose <66 Gy, an extended RP to SRT interval, and older age (p < 0.05 for every). Elements related to DM embrace PSA DT <6 mo, pre-SRT PSA, a better GS, and detrimental margins. Elements related to PCSM embrace PSA DT not calculable or <6 mo and a better GS. Nomograms have been generated to estimate the dangers of BF (concordance index [CI] 0.74), DM (CI 0.77), and PCSM (CI 0.77). Limitations embrace retrospective nature, broad remedy eras, institutional variations, and a number of strategies out there for the estimation of PSA DT.

Conclusions: Postoperative PSA kinetics, significantly pre-SRT PSA and PSA DT, are strongly related to antagonistic oncologic outcomes following SRT and ought to be thought-about in administration selections.

Affected person abstract: On this report of males with prostate most cancers who developed a prostate-specific antigen (PSA) recurrence after prostatectomy, we discovered that PSA ranges after surgical procedure and the way shortly a PSA stage doubles considerably impression the possibility of prostate most cancers recurrence after salvage radiation remedy. Based mostly on this data, we created a device to calculate a person’s probability of most cancers recurrence after salvage radiation remedy, and these estimations can be utilized to debate whether or not extra remedy with radiation ought to be thought-about.

formulapharma
formulapharma

Mouse Stem Cell Factor (SCF) AssayMax ELISA Kit

EMS1001-1 96 Well Plate
EUR 396

Mouse Nanog Stem Cell Differentiation Reporter (pGreenZeo, plasmid)

SR10031PA-1 10 ug
EUR 1749

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 280

Mouse Nanog Stem Cell Differentiation Reporter (pGreenZeo, pre-packaged)

SR10031VA-1 >2 x 10^6 IFUs
EUR 755

SCF Stem Cell Factor Human Recombinant Protein

PROTP21583-1 Regular: 10ug
EUR 317
Description: Stem Cell Factor Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 165 amino acids and having a molecular mass of 18409 Dalton. ;The SCF is purified by proprietary chromatographic techniques.

StemBoost? Neural Stem Cell Reprogramming Cocktail (100X)

S238-1
EUR 185

SCA-1 Antibody

47996-100ul 100ul
EUR 333

SCA-1 Antibody

47996-50ul 50ul
EUR 239

Human Stem Cell Factor (SCF) AssayMax ELISA Kit

ES1001-1 96 Well Plate
EUR 396

Mouse Prostate stem cell antigen (Psca)

1-CSB-YP018840MO
  • EUR 504.00
  • EUR 265.00
  • EUR 1832.00
  • EUR 763.00
  • EUR 1216.00
  • EUR 334.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Mouse Prostate stem cell antigen(Psca) expressed in Yeast

SCA-1 Conjugated Antibody

C47996 100ul
EUR 397

Anti-PARP-1 Antibody

A00122-1 100ul
EUR 397
Description: Rabbit Polyclonal PARP-1 Antibody. Validated in ELISA, IP, IF, WB and tested in Human, Mouse.

Anti-Presenilin 1 Antibody

A00138-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for Presenilin 1 Antibody (PSEN1) detection. Tested with WB, IHC in Human, Mouse, Rat.

Anti-PAI-1 Antibody

A00637-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for PAI-1 Antibody (SERPINE1) detection.tested for WB in Human, Mouse, Rat.

Anti-Flk-1 Antibody

A00901-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for Flk-1 Antibody (KDR) detection.tested for WB in Human, Mouse.

Anti-EDG-1 Antibody

A01502-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for EDG-1 Antibody (S1PR1) detection.tested for WB in Human, Mouse, Rat.

Anti-ROBO-1 Antibody

A01530-1 100ug
EUR 455
Description: Rabbit Polyclonal ROBO-1 Antibody. Validated in IF, IHC, WB and tested in Human, Mouse, Rat.

Anti-TFIIIB90-1 Antibody

A03761-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for TFIIIB90-1 Antibody (BRF1) detection.tested for WB in Human, Mouse.

Anti-Atrophin-1 Antibody

A03828-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for Atrophin-1 Antibody (ATN1) detection. Tested with WB in Human, Mouse, Rat.

Anti-CNG-1 Antibody

A05494-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for CNG-1 Antibody (CNGA1) detection. Tested with WB in Human, Mouse, Rat.

Anti-Periphilin 1 Antibody

A06996-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for Periphilin 1 Antibody (PPHLN1) detection.tested for WB in Human, Mouse.

Anti-Lyl-1 Antibody

A07491-1 100ul
EUR 397
Description: Rabbit Polyclonal Lyl-1 Antibody. Validated in IHC and tested in Human, Mouse, Rat.

Anti-GLI-1 Antibody

A07972-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for GLI-1 Antibody (ACSS1) detection. Tested with WB in Human, Mouse, Rat.

Anti-Cerebellin 1 Antibody

A09176-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for Cerebellin 1 Antibody (CBLN1) detection. Tested with WB in Human, Mouse, Rat.

Anti-DOC-1 Antibody

A09467-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for DOC-1 Antibody (CDK2AP1) detection. Tested with WB in Human, Mouse.

Anti-Bag-1 Antibody

A02423-1 50 ul
EUR 397
Description: Rabbit Polyclonal Bag-1 Antibody. Validated in IP, IHC and tested in Bovine, Canine, Human, Mouse, Rat.

Anti-TUB 1 Antibody

A02917-1 100ug/vial
EUR 294

Anti-Dok-1 Antibody

A03039-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for Dok-1 Antibody (DOK1) detection.tested for WB in Human, Mouse, Rat.

Anti-NPDC-1 Antibody

A12846-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for NPDC-1 Antibody (NPDC1) detection. Tested with WB in Human, Mouse, Rat.

Anti-HO-1 Monoclonal Antibody (HO-1-2)

M00253-1 1mg
EUR 397
Description: Mouse Monoclonal HO-1 Antibody (HO-1-2). Validated in Flow Cytometry, IHC, WB and tested in Human, Mouse, Rat.

Anti-Esrp-1 Monoclonal Antibody

M06068-1 100uL
EUR 443
Description: Mouse Monoclonal Esrp-1 Antibody. Validated in WB and tested in Human.

Anti-Presenilin 1 Monoclonal Antibody

M00138-1 100ug
EUR 397
Description: Rabbit Monoclonal Presenilin 1 Antibody. Validated in WB and tested in Human, Mouse, Rat.

Anti-Galectin 1 Monoclonal Antibody

M00470-1 100ug
EUR 397
Description: Rabbit Monoclonal Galectin 1 Antibody. Validated in IP, IF, WB and tested in Human, Mouse, Rat.

Anti-DJ-1 Monoclonal Antibody

M00757-1 100ul
EUR 397
Description: Mouse Monoclonal DJ-1 Antibody. Validated in IHC, WB and tested in Bovine, Human.

Anti-Enolase 1 Monoclonal Antibody

M01250-1 100ul
EUR 397
Description: Anti-Enolase 1 Monoclonal Antibody tested in WB, IF, ICC, IHC, reactive to Human, rat, mouse, cow, pig, horse

Anti-Dynamin 1 Monoclonal Antibody

M02536-1 100ug
EUR 397
Description: Rabbit Monoclonal Dynamin 1 Antibody. Validated in IF, WB and tested in Human, Mouse, Rat.

Anti-Angiopoietin 1/ANGPT1 Antibody

PA1333-1 100ug/vial
EUR 334

Anti-Galectin 1/LGALS1 Antibody

PB9240-1 100ug/vial
EUR 334

Anti-TNF Receptor 1 Antibody

A00294-1 200ug
EUR 522
Description: Rabbit Polyclonal TNF Receptor 1 Antibody. Validated in IP, IHC, WB and tested in Human, Mouse, Rat.

Anti-Galectin 1/Lgals1 Antibody

A00470-1 100ug/vial
EUR 334

Anti-LOX-1/OLR1 Antibody

A00760-1 100ug/vial
EUR 294

Anti-Syndecan-1/SDC1 Antibody

A00991-1 100ug/vial
EUR 294

Anti-IRAK-1/IRAK1 Antibody

A01021-1 100ug/vial
EUR 334

Anti-Neurexin 1/NRXN1 Antibody

A01490-1 100ug/vial
EUR 334

Anti-Hexokinase 1/HK1 Antibody

A01504-1 100ug/vial
EUR 334

Anti-Musashi 1/Msi1 Antibody

A05052-1 100ug/vial
EUR 334

Anti-Pyrophosphatase 1/PPA1 Antibody

A07485-1 100ug/vial
EUR 334

Anti-TCP-1 eta Antibody

A08169-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for TCP-1 eta Antibody (CCT7) detection. Tested with WB in Human, Mouse, Rat.

Anti-Relaxin 1/RLN1 Antibody

A08367-1 100ug/vial
EUR 334

Anti-TCP-1 zeta Antibody

A09373-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for TCP-1 zeta Antibody (CCT6A) detection.tested for WB in Human, Mouse, Rat.

Anti-Synaptotagmin 1/SYT1 Antibody

A02314-1 100ug/vial
EUR 334

Anti-Syntenin-1 Monoclonal Antibody

A02475-1 100ul
EUR 397
Description: Mouse Monoclonal Antibody for Syntenin-1 Antibody (SDCBP) detection. Tested with WB in Human, Rat, Dog, Pig.

Anti-Dsg1/Desmoglein 1 Antibody

A02655-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for Dsg1 Antibody (DSG1) detection.tested for IHC, WB in Human, Mouse, Rat.

Anti-CAF-1 p150 Antibody

A02732-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for CAF-1 p150 Antibody (CHAF1A) detection. Tested with WB in Human, Mouse.

Anti-Talin 1/TLN1 Antibody

A02859-1 100ug/vial
EUR 334

Anti-Islet 1/ISL1 Antibody

A02969-1 100ug/vial
EUR 334

Anti-CHST8/Galnac4St 1 Antibody

A10989-1 100ul
EUR 397
Description: Rabbit Polyclonal CHST8/Galnac4St 1 Antibody. Validated in WB and tested in Human, Mouse, Rat.

Prostate Stem Cell Antigen Antibody

33476-100ul 100ul
EUR 252

Prostate Stem Cell Antigen Antibody

33476-50ul 50ul
EUR 187

Prostate Stem Cell Antigen Antibody

ABD8709 100 ug
EUR 438

Prostate Stem Cell Antigen Antibody

DF8709 200ul
EUR 304
Description: Prostate Stem Cell Antigen Antibody detects endogenous levels of total Prostate Stem Cell Antigen.

CF350 Goat Anti-Mouse IgG1 (γ1), 2mg/mL

20245-1 50uL
EUR 149
Description: Minimum order quantity: 1 unit of 50uL

CF488A Goat Anti-Mouse IgG1 (γ1), 2mg/mL

20246-1 50uL
EUR 149
Description: Minimum order quantity: 1 unit of 50uL

CF555 Goat Anti-Mouse IgG1 (γ1), 2mg/mL

20247-1 50uL
EUR 149
Description: Minimum order quantity: 1 unit of 50uL

CF568 Goat Anti-Mouse IgG1 (γ1), 2mg/mL

20248-1 50uL
EUR 149
Description: Minimum order quantity: 1 unit of 50uL

CF594 Goat Anti-Mouse IgG1 (γ1), 2mg/mL

20249-1 50uL
EUR 149
Description: Minimum order quantity: 1 unit of 50uL

CF633 Goat Anti-Mouse IgG1 (γ1), 2mg/mL

20250-1 50uL
EUR 149
Description: Minimum order quantity: 1 unit of 50uL

CF640R Goat Anti-Mouse IgG1 (γ1), 2mg/mL

20251-1 50uL
EUR 149
Description: Minimum order quantity: 1 unit of 50uL

CF647 Goat Anti-Mouse IgG1 (γ1), 2mg/mL

20252-1 50uL
EUR 149
Description: Minimum order quantity: 1 unit of 50uL

CF680 Goat Anti-Mouse IgG1 (γ1), 2mg/mL

20253-1 50uL
EUR 161
Description: Minimum order quantity: 1 unit of 50uL

CF770 Goat Anti-Mouse IgG1 (γ1), 2mg/mL

20254-1 50uL
EUR 161
Description: Minimum order quantity: 1 unit of 50uL

CF543 Goat Anti-Mouse IgG1 (γ1), 2mg/mL

20325-1 50uL
EUR 149
Description: Minimum order quantity: 1 unit of 50uL

Hemokinin 1 (mouse)

B5127-1 1 mg
EUR 321

Anti-BOB-1/OBF-1 Rabbit Monoclonal Antibody, Clone#RM378

M04431-1 100uL
EUR 385
Description: Anti-BOB-1/OBF-1 Rabbit Monoclonal Antibody, Clone#RM378 tested in WB, IHC, reactive to Human

AXMIR-1 RNA oligo anti-miRNA-1-3p with Xmotif

AXMIR-1 10 reactions
EUR 438

Anti-Sumo 1 Rabbit Monoclonal Antibody

M00631-1 100ug/vial
EUR 397
Description: Rabbit Monoclonal Sumo 1 Antibody. Validated in IP, IF, IHC, WB and tested in Human, Mouse, Rat.

Anti-Cytokeratin 1 Rabbit Monoclonal Antibody

M01639-1 100ug/vial
EUR 397
Description: Rabbit Monoclonal Cytokeratin 1 Antibody. Validated in WB and tested in Human, Mouse, Rat.

Anti-Mitofusin 1 Antibody (monoclonal, 3H3)

M02172-1 100ug/vial
EUR 294

Anti-Phospho-Beclin-1 (Ser295) Antibody

P00327-1 100ul
EUR 398
Description: Rabbit Polyclonal Phospho-Beclin-1 (Ser295) Antibody. Validated in WB and tested in Human.

Anti-Phospho-Raf-1 (Ser642) Antibody

P00446-1 100ul
EUR 398
Description: Rabbit Polyclonal Phospho-Raf-1 (Ser642) Antibody. Validated in WB and tested in Human, Rat.

Anti-Integrin alpha 1/ITGA1 Antibody

PA1045-1 100ug/vial
EUR 334

Anti-Caspase-1(P20)/CASP1 Antibody

PA1440-1 100ug/vial
EUR 294

Anti-VEGF Receptor 1/FLT1 Antibody

PA1966-1 100ug/vial
EUR 294

Anti-HIF-1 alpha/HIF1A Antibody

A00013-1 100ug/vial
EUR 294

Anti-Cleaved-Notch 1 (V1754) Antibody

A00033-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for Cleaved-Notch 1 (V1754) Antibody (NOTCH1) detection.tested for WB in Human, Mouse, Rat.

Anti-HDAC-1 (C-terminus) Antibody

A00256-1 100uL
EUR 443
Description: Rabbit Polyclonal HDAC-1 (C-terminus) Antibody. Validated in IF, IHC, WB and tested in Human.

Anti-VEGF Receptor 1/FLT1 Antibody

A00534-1 100ug/vial
EUR 294

Anti-Liver Carboxylesterase 1/CES1 Antibody

A01741-1 100ug/vial
EUR 334

Anti-Hyaluronan synthase 1/HAS1 Antibody

A04784-1 100ug/vial
EUR 334

Anti-CELSR3/Flamingo Homolog 1 Antibody

A07204-1 100ul
EUR 397
Description: Rabbit Polyclonal CELSR3/Flamingo Homolog 1 Antibody. Validated in IF and tested in Human, Mouse, Rat.

Anti-LPCAT2/Acyltransferase Like 1 Antibody

A07471-1 100ul
EUR 397
Description: Rabbit Polyclonal LPCAT2/Acyltransferase Like 1 Antibody. Validated in WB and tested in Human, Mouse, Rat.

Anti-EBP50/NHERF-1/SLC9A3R1 Antibody

A02427-1 100ug/vial
EUR 334

Anti-IL1R2/Il 1 Rii Antibody

A03106-1 1 ml
EUR 397
Description: Rabbit Polyclonal IL1R2/Il 1 Rii Antibody. Validated in IP, WB and tested in Human.

Anti-TTF-1

DB-089-1 1 ml
EUR 750
Description: rabbit monospecific clonal antibodies for ihc-p application; concentrated

TINAGL1 Human, Tubulointerstitial Nephritis Antigen Like 1 Human Recombinant Protein, Sf9

PROTQ9GZM7-1 Regular: 5ug
EUR 317
Description: TINAGL1 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 455 amino acids (22-467a.a.) and having a molecular mass of 51.2kDa (Molecular size on SDS-PAGE will appear at approximately 50-70kDa). TINAGL1 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Podocalyxin (PODXL) (Hematopoietic Stem Cell Marker); Clone 3D3 (Concentrate)

RA0264-C.1 0.1 ml
EUR 125

Human T-Cell Antigen CD7 (CD7) AssayMax ELISA Kit

EC3502-1 96 Well Plate
EUR 477

StemTAG Stem Cell Colony Formation Assay (Cell Recovery Compatible)

CBA-325 96 assays
EUR 856
Description: Our StemTAG 96-Well Stem Cell Colony Formation Assay provides a high-throughput method to quantify ES cells in just 7-10 days, and no manual cell counting is required. Once colonies are formed, they may be analyzed in three different ways: 1. Lyse cells, then quantify in a fluorescence plate reader using dye included in the kit; 2. Lyse cells, then quantify alkaline phosphatase activity using reagents provided; or 3. Recover colonies from matrix for further culture or analysis.

StemTAG Stem Cell Colony Formation Assay (Cell Recovery Compatible)

CBA-325-5 5 x 96 assays
EUR 3361
Description: Our StemTAG 96-Well Stem Cell Colony Formation Assay provides a high-throughput method to quantify ES cells in just 7-10 days, and no manual cell counting is required. Once colonies are formed, they may be analyzed in three different ways: 1. Lyse cells, then quantify in a fluorescence plate reader using dye included in the kit; 2. Lyse cells, then quantify alkaline phosphatase activity using reagents provided; or 3. Recover colonies from matrix for further culture or analysis.

Anti-Musashi 1/Msi1 Antibody (monoclonal, 2B9)

M05052-1 100ug/vial
EUR 334

Proposed Framework for Contemplating SARS-CoV-2 Antigen Testing of Unexposed Asymptomatic Staff in Chosen Workplaces

asymptomatic staff in chosen workplaces.

Strategies: This can be a commentary based mostly on established occupational security and well being rules, revealed articles, and different pertinent literature, together with non-peer-reviewed preprints in medrixiv.org previous to April 16, 2021.

Outcomes: Not relevant to this commentary/viewpoint article.

Conclusion: Antigen testing is a quickly evolving and helpful public well being device that can be utilized to information measures to cut back unfold of SARS-CoV-2 in the neighborhood and in chosen workplaces. This commentary supplies a proposed framework for occupational security and well being practitioners and employers for contemplating antigen testing as a way to display asymptomatic staff in chosen non-healthcare settings. When utilized selectively, antigen testing could be a helpful, efficient a part of a complete office program for COVID-19 prevention and management.

Affiliation of single-nucleotide polymorphisms in tumour necrosis issue and human leukocyte antigens genes with sort 1 diabetes

Kind 1 diabetes (T1D) is an autoimmune illness characterised by progressive destruction of insulin-producing pancreatic beta cells. This multifactorial illness has a sturdy genetic part related to the human leukocyte antigens (HLA) and non-HLA areas. On this research, we in contrast frequencies of HLA-DRB1 alleles and single-nucleotide polymorphisms (SNPs) related the genes coding for: toll-like receptors (TLRs), tumour necrosis issue (TNF), interleukin-1 (IL-1), interleukin-1 receptor sort 1 (IL-1R1), interleukin-1 receptor antagonist (IL-1RN), interleukin-2 (IL-2) and interleukin-12B (IL-12B), between T1D sufferers and wholesome controls.

The intention was to establish frequency variations and linkage between these genetic markers in T1D sufferers and wholesome controls. Twelve SNPs have been investigated as follows: rs16944 (IL-1B), rs1143634 (IL-1B), rs1800587 (IL-1A), rs2069762 (IL-2), rs3212227 (IL-12B), rs2234650 (IL-1R1), rs315952 (IL-1RN), rs3804099 (TLR2), rs4986790 (TLR4), rs4986791 (TLR4), rs1800629 (TNF) and rs361525 (TNF). TaqMan genotype assay methodology was used for SNPs genotyping. HLA-DRB1* genes have been typed by Sequence Particular Oligonucleotide Probe (SSOP). SPSS and SNPStats packages have been used for the statistical evaluation. Vital variations between T1D and management teams have been discovered for the dominant mannequin of rs361525 and rs1800629A:rs361525G genotypes for TNF.

Elevated frequencies of DRB1*03 and DRB1*04 and decreased frequencies of DRB1*07, DRB1*11 and DRB1*13 and DRB1*15 have been noticed in T1D sufferers in contrast with controls. Nonetheless, the genotype, DRB1*07 with rs1800629A/G was related to T1D. Now we have confirmed that DRB1*03 and DRB1*04 are related to elevated danger and DRB1*07, DRB1*11 and DRB1*13 and DRB1*15 with decreased danger of T1D. Additionally, the dominant mannequin of rs361525A, and the rs1800629G:361525A genotype have been related to elevated danger. The simultaneous presence of DRB1*07 and rs1800629A/G genotypes in 23 out of 27 DRB1*07 optimistic T1D sufferers implied that islet cell peptide processing could have been biased in direction of autoimmunity by upregulation of TNF related intronic SNPs.

Are chimeric antigen receptor T cells (CAR-T cells) the long run in immunotherapy for autoimmune illnesses?

Goal: CAR-T cell remedy has revolutionized the remedy of oncological illnesses, and potential makes use of in autoimmune illnesses have lately been described. The assessment goals to combine the out there knowledge on remedy with CAR-T cells, emphasizing autoimmune illnesses, to find out therapeutic advances and their doable future scientific applicability in autoimmunity.

Supplies and strategies: A search was carried out in PubMed with the key phrases “Chimeric Antigen Receptor” and “CART cell”. The paperwork of curiosity have been chosen, and a vital assessment of the data was carried out.

Outcomes: Within the remedy of autoimmune illnesses, in preclinical fashions, three totally different mobile methods have been used, which embrace Chimeric antigen receptor T cells, Chimeric autoantibody receptor T cells, and Chimeric antigen receptor in regulatory T lymphocytes. All three varieties of remedy have been efficient. The potential antagonistic results inside them, cytokine launch syndrome, mobile toxicity and neurotoxicity should at all times be saved in thoughts.

Conclusions: Though data in people will not be but out there, preclinical fashions of CAR-T cells within the remedy of autoimmune illnesses present promising outcomes, in order that sooner or later, they might develop into a helpful and efficient remedy within the remedy of those pathologies.

anti-CD300 antigen

YF-PA17583 50 ul
EUR 363
Description: Mouse polyclonal to CD300 antigen

anti-CD300 antigen

YF-PA17584 50 ug
EUR 363
Description: Mouse polyclonal to CD300 antigen

anti-CD300 antigen

YF-PA17585 50 ul
EUR 363
Description: Mouse polyclonal to CD300 antigen

Mouse Anti-EBV Nuclear Antigen Monoclonal Antibody

DMAB3332-05mg 0.5 mg
EUR 969

Mouse Anti-EBV Nuclear Antigen Monoclonal Antibody

DMAB3332-1mg 1 mg
EUR 1469

Mouse Anti Melanoma associated antigen ELISA kit

E03M0220-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Mouse Anti Melanoma associated antigen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Anti Melanoma associated antigen ELISA kit

E03M0220-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Mouse Anti Melanoma associated antigen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Anti Melanoma associated antigen ELISA kit

E03M0220-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Mouse Anti Melanoma associated antigen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Anti soluble liver antigen ELISA kit

E03S0263-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Mouse Anti soluble liver antigen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Anti soluble liver antigen ELISA kit

E03S0263-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Mouse Anti soluble liver antigen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Anti soluble liver antigen ELISA kit

E03S0263-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Mouse Anti soluble liver antigen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Anti-Carcinoembryonic Antigen antibody

STJ16100878 1 mL
EUR 668

Anti-Nucleolar Antigen antibody

STJ16101002 100 µg
EUR 354

Anti-Liver Antigen antibody

STJ16101073 100 µg
EUR 354

Anti-Liver Antigen antibody

STJ16101074 100 µg
EUR 354

Anti-Ku80 Antigen Purified

11-496-C025 0.025 mg
EUR 108

Anti-Ku80 Antigen Purified

11-496-C100 0.1 mg
EUR 177

Anti-Carcinoembryonic Antigen antibody

STJ96963 200 µl
EUR 197
Description: Carcinoembryonic antigen is a protein encoded by the CEACAM5 gene which is approximately 76,7 kDa. Carcinoembryonic antigen is localised to the cell membrane. It is involved in the metabolism of proteins and hematopoietic stem cell differentiation pathways and lineage-specific markers. It is a cell surface glycoprotein that plays a role in cell adhesion and in intracellular signalling. It may also regulate differentiation, apoptosis, and cell polarity and is used as a clinical biomarker for gastrointestinal cancers. Carcinoembryonic antigen is expressed in the intestine, liver, saliva, stomach and lung. Mutations in the CEACAM5 gene may be involved in urachal cancer. STJ96963 was developed from clone 10E1 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This primary antibody detects endogenous Carcinoembryonic antigen proteins.

anti-Prostate Specific Antigen

YF-PA10281 50 ug
EUR 363
Description: Mouse polyclonal to Prostate Specific Antigen

anti-Prostate Specific Antigen

YF-PA10282 100 ug
EUR 403
Description: Rabbit polyclonal to Prostate Specific Antigen

Mouse Anti-Bacillus anthracis Protective Antigen Monoclonal Antibody

DMAB3024 1 mg
EUR 903

Mouse Anti-Bacillus anthracis Protective Antigen Monoclonal Antibody

DMAB3028 1 mg
EUR 955

Mouse Anti-Bacillus anthracis Protective Antigen Monoclonal Antibody

DMAB3029 1 mg
EUR 955

Mouse Anti-Bacillus anthracis Protective Antigen Monoclonal Antibody

DMAB3031 1 mg
EUR 903

Mouse Anti-Bacillus anthracis Spore Antigen Monoclonal Antibody

DMAB3033-05mg 0.5 mg
EUR 969

Mouse Anti-Bacillus anthracis Spore Antigen Monoclonal Antibody

DMAB3033-1mg 1 mg
EUR 1469

Mouse Anti-Bacillus anthracis Spore Antigen Monoclonal Antibody

DMAB3034-05mg 0.5 mg
EUR 969

Mouse Anti-Bacillus anthracis Spore Antigen Monoclonal Antibody

DMAB3034-1mg 1 mg
EUR 1469

Mouse Anti-Hepatitis B Core Antigen Monoclonal Antibody

DMAB3498 1 mg
EUR 833

Mouse Anti-Hepatitis B Surface Antigen Monoclonal Antibody

DMAB3525 1 mg
EUR 781

Mouse Anti-Hepatitis B Surface Antigen Monoclonal Antibody

DMAB3531 1 mg
EUR 741

Mouse Anti-Hepatitis B Surface Antigen Monoclonal Antibody

DMAB3532 1 mg
EUR 741

Mouse Anti-Hepatitis B Surface Antigen Monoclonal Antibody

DMAB3536-05mg 0.5 mg
EUR 969

Mouse Anti-Hepatitis B Surface Antigen Monoclonal Antibody

DMAB3536-1mg 1 mg
EUR 1469

Mouse Anti-Hepatitis B Surface Antigen Monoclonal Antibody

DMAB3537-05mg 0.5 mg
EUR 969

Mouse Anti-Hepatitis B Surface Antigen Monoclonal Antibody

DMAB3537-1mg 1 mg
EUR 1469

Mouse Anti-Hepatitis B Surface Antigen Monoclonal Antibody

DMAB3540 1 mg
EUR 741

Mouse Anti-Hepatitis B Surface Antigen Monoclonal Antibody

DMAB3543 1 mg
EUR 741

Mouse Anti-Hepatitis B Surface Antigen Monoclonal Antibody

DMAB3545 1 mg
EUR 632

Mouse Anti-Hepatitis B Surface Antigen Monoclonal Antibody

DMAB3546 1 mg
EUR 632

Mouse Anti Borrelia Burgdorferi Flagellar Antigen Monoclonal Antibody

DMABT-51105MB 0.2 mg
EUR 715

Mouse Anti Chlamydia Trachomatis 30Kda Antigen Monoclonal Antibody

DMABT-51152MC 0.2 mg
EUR 663

Mouse Anti Hepatitis A Surface Antigen Monoclonal Antibody

DMABT-51310MH 0.2 mg
EUR 741

Mouse Anti Hepatitis B Core Antigen Monoclonal Antibody

DMABT-51311MH 0.2 mg
EUR 767

Mouse Anti Hepatitis B Core Antigen Monoclonal Antibody

DMABT-51312MH 0.2 mg
EUR 710

Mouse Anti Hepatitis B Core Antigen Monoclonal Antibody

DMABT-51314MH 0.2 mg
EUR 580

Mouse Anti Hepatitis B Core Antigen Monoclonal Antibody

DMABT-51315MH 0.2 mg
EUR 710

Mouse Anti Hepatitis B Core Antigen Monoclonal Antibody

DMABT-51316MH 0.2 mg
EUR 663

Mouse Anti Hepatitis B Core Antigen Monoclonal Antibody

DMABT-51317MH 0.2 mg
EUR 710

Mouse Anti Hepatitis B E Antigen Monoclonal Antibody

DMABT-51319MH 0.2 mg
EUR 767

Mouse Anti Hepatitis B Surface Antigen Monoclonal Antibody

DMABT-51323MH 0.2 mg
EUR 580

Mouse Anti Hepatitis B Surface Antigen Monoclonal Antibody

DMABT-51324MH 0.1 ml
EUR 445

Mouse Anti Hepatitis B Surface Antigen Monoclonal Antibody

DMABT-51325MH 1 ml
EUR 819

Mouse Anti Hepatitis B Surface Antigen Monoclonal Antibody

DMABT-51326MH 1 ml
EUR 445

Mouse Anti Hepatitis B Surface Antigen Monoclonal Antibody

DMABT-51327MH 6 ml
EUR 715

Mouse Anti Hepatitis B Surface Antigen Monoclonal Antibody

DMABT-51328MH 0.1 mg
EUR 741

Mouse Anti Hepatitis B X Antigen Monoclonal Antibody

DMABT-51330MH 0.25 mg
EUR 725

Mouse Anti Hepatitis C Core Antigen Monoclonal Antibody

DMABT-51332MH 0.1 mg
EUR 767

Mouse Anti Hepatitis C E1 Antigen Monoclonal Antibody

DMABT-51333MH 0.1 mg
EUR 944

Mouse Anti Hepatitis C E2 Antigen Monoclonal Antibody

DMABT-51334MH 0.1 mg
EUR 944

Mouse Anti Influenza A H5 Antigen Monoclonal Antibody

DMABT-51386MI 0.2 mg
EUR 663

Mouse Anti Influenza A H5 Antigen Monoclonal Antibody

DMABT-51388MI 0.2 mg
EUR 741

Mouse Anti Mycobacterium Tuberculosis 16Kda Antigen Monoclonal Antibody

DMABT-51441MM 0.1 mg
EUR 892

Mouse Anti Mycobacterium Tuberculosis 16Kda Antigen Monoclonal Antibody

DMABT-51442MM 0.1 mg
EUR 892

Mouse Anti Mycobacterium Tuberculosis 38Kda Antigen Monoclonal Antibody

DMABT-51444MM 0.2 mg
EUR 767

Mouse Anti Mycobacterium Tuberculosis 38Kda Antigen Monoclonal Antibody

DMABT-51446MM 0.2 mg
EUR 767

Mouse Anti Mycobacterium Tuberculosis 38Kda Antigen Monoclonal Antibody

DMABT-51448MM 0.2 mg
EUR 767

Mouse Anti Yersinia Pestis V Antigen Monoclonal Antibody

DMABT-51632MY 0.2 mg
EUR 767

Mouse Anti Yersinia Pestis V Antigen Monoclonal Antibody

DMABT-51634MY 0.2 mg
EUR 767

Rat Anti Mouse F4/80 Antigen Monoclonal Antibody

CABT-47632RM 0.1 mg
EUR 663

Mouse anti- extractable nuclear antigen antibody ELISA Kit

ELA-E1124m 96 Tests
EUR 865

Mouse IgG Antigen

IM122 1 ml
EUR 285
Description: Mouse IgG Antigen by Cygnus Technologies is available in Europe via Gentaur.

anti-RhoD human antigen IgG1

131-A-01mg 0,1 mg
EUR 267.5
Description: anti-RhoD human antigen IgG1

anti-RhoD human antigen IgG1

131-A-1000ug 1000 ug
EUR 1282.5
Description: anti-RhoD human antigen IgG1

Anti-HLA-DR antigen antibody

STJ16100045 1 mL
EUR 478

Anti-CD95/FAS antigen antibody

STJ16100141 100 µg
EUR 354

Anti-Rat CD4-antigen antibody

STJ16100150 1 mL
EUR 604

Anti-Myeloid Specific Antigen antibody

STJ16100158 100 µg
EUR 389

Anti-Myeloid Specific Antigen antibody

STJ16100170 100 µg
EUR 389

Anti-Myeloid Specific Antigen antibody

STJ16100171 100 µg
EUR 389

Anti-Myeloid Specific Antigen antibody

STJ16100172 100 µg
EUR 389

Anti-Hepatocyte Specific Antigen antibody

STJ16100376 1 mL
EUR 795

Anti-Melamona-Associated Antigen antibody

STJ16100389 1 mL
EUR 871

Anti-Melamona-Associated Antigen antibody

STJ16100390 1 mL
EUR 838

Anti-Melanoma Discr. Antigen antibody

STJ16100730 1 mL
EUR 290

Anti-Melanoma Discr. Antigen antibody

STJ16100731 1 mL
EUR 290

Anti-Melanoma Associated Antigen antibody

STJ16100732 1 mL
EUR 253

Anti-Melanoma Associated Antigen antibody

STJ16100733 1 mL
EUR 271

Anti-Melanoma Associated Antigen antibody

STJ16100734 1 mL
EUR 271

Anti-Melanoma Associated Antigen antibody

STJ16100735 1 mL
EUR 271

Anti-Ovarium Carcinoma Antigen antibody

STJ16100873 1 mL
EUR 290

Anti-Leukocyte Common Antigen antibody

STJ16100941 1 mL
EUR 481

Anti-Prostate Specific Antigen antibody

STJ16100961 1 mL
EUR 481

Anti-Myeloid Specific Antigen antibody

STJ16100989 100 µg
EUR 354

Anti-Anthrax Protective Antigen antibody

STJ99283 200 µl
EUR 197
Description: Mouse monoclonal to Anthrax Protective Antigen.

anti-Carcinoembryonic Antigen/CEA (10E1)

LF-MA20354 100 ug
EUR 354
Description: Mouse monoclonal to Carcinoembryonic Antigen (CEA)

Anti-Prostate Specific Antigen (1B1)

YF-MA11962 100 ug
EUR 363
Description: Mouse monoclonal to Prostate Specific Antigen

anti-Blood Group Kell Antigen

YF-PA12828 50 ul
EUR 363
Description: Mouse polyclonal to Blood Group Kell Antigen

Anti-Flavivirus group antigen Antibody

A1146-200
EUR 697

Anti-Flavivirus group antigen Antibody

A1147-200
EUR 697

anti-NY-REN-50 antigen

YF-PA19832 50 ul
EUR 363
Description: Mouse polyclonal to NY-REN-50 antigen

Mouse Anti Epstein-Barr Virus Nuclear Antigen Monoclonal Antibody

DMABT-51237ME 0.1 mg
EUR 819

Mouse Anti Epstein-Barr Virus Nuclear Antigen Monoclonal Antibody

DMABT-51238ME 0.1 mg
EUR 715

Mouse Anti Hepatitis B Core Antigen Monoclonal Antibody,HRP

DMABT-51313MH 0.1 mg
EUR 767

Mouse Anti Hepatitis C Ns-3 Antigen Monoclonal Antibody

DMABT-51336MH 0.2 mg
EUR 767

Mouse Anti Hepatitis C Ns-3 Antigen Monoclonal Antibody

DMABT-51337MH 0.2 mg
EUR 767

Mouse Anti Hepatitis C Ns-3 Antigen Monoclonal Antibody

DMABT-51338MH 0.2 mg
EUR 767

Mouse Anti Hepatitis C Ns-3 Antigen Monoclonal Antibody

DMABT-51339MH 0.1 mg
EUR 944

Mouse Anti Hepatitis C Ns-3 Antigen Monoclonal Antibody

DMABT-51340MH 0.1 mg
EUR 944

Mouse Anti Hepatitis C Ns-3 Antigen Monoclonal Antibody

DMABT-51341MH 0.1 mg
EUR 1261

Mouse Anti Hepatitis C Ns-4A Antigen Monoclonal Antibody

DMABT-51344MH 0.1 mg
EUR 944

Mouse Anti Hepatitis C Ns-5 Antigen Monoclonal Antibody

DMABT-51346MH 0.2 mg
EUR 767

Mouse Anti Hepatitis C Ns-5 Antigen Monoclonal Antibody

DMABT-51348MH 0.2 mg
EUR 767

Mouse Anti Hepatitis C Ns-5A Antigen Monoclonal Antibody

DMABT-51351MH 0.1 mg
EUR 1261

Rat Anti Mouse F4/80 Antigen Monoclonal Antibody,APC

CABT-47617RM 100 TEST
EUR 767

Rat Anti Mouse F4/80 Antigen Monoclonal Antibody,Biotin

CABT-47620RM 0.1 mg
EUR 741

Rat Anti Mouse F4/80 Antigen Monoclonal Antibody,FITC

CABT-47625RM 0.1 mg
EUR 741

Mouse Monoclonal Anti-Hepatitis Surface Antigen (HBsAg)-HRP Conjugate

HBA12-HRP 1 ml
EUR 347

Mouse Monoclonal Anti-Hepatitis Surface Antigen (HBsAg) (clone 1)

HBA12-M 1 mg
EUR 286

Mouse Monoclonal Anti-Hepatitis Surface Antigen (HBsAg) (clone 2)

HBA13-M 1 mg
EUR 286

Mouse Monoclonal Anti-human carcinoembryonic antigen (CEA) (clone 1)

CEA11-M 500 ug
EUR 482

Mouse Monoclonal Anti-human carcinoembryonic antigen (CEA) (clone 2)

CEA12-M 500 ug
EUR 482

Mouse Anti paraneoplastic Ma antigen 2 antibody ELISA kit

E03A0480-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Mouse Anti paraneoplastic Ma antigen 2 antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Anti paraneoplastic Ma antigen 2 antibody ELISA kit

E03A0480-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Mouse Anti paraneoplastic Ma antigen 2 antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Anti paraneoplastic Ma antigen 2 antibody ELISA kit

E03A0480-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Mouse Anti paraneoplastic Ma antigen 2 antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Anti-Prostate Specific Antigen/KLK3 Antibody

PB9259 100ug/vial
EUR 294

anti-Rabies G antigen monoclonal antibody

010-A-01mg 0,1 mg
EUR 267.5
Description: anti-Rabies G antigen monoclonal antibody. Produced against a recombinant protein.

anti-Rabies G antigen monoclonal antibody

010-A-1000ug 1000 ug
EUR 1282.5
Description: anti-Rabies G antigen monoclonal antibody. Produced against a recombinant protein.

Anti-HBcAG Hepatitis B Core Antigen

030-A-01mg 0,1 mg
EUR 267.5
Description: anti-HBcAg core IgM (monoclonal) Produced against recombinant HBcAg core antigen.

Anti-HBcAG Hepatitis B Core Antigen

030-A-1000ug 1000 ug
EUR 1282.5
Description: anti-HBcAg core IgM (monoclonal) Produced against recombinant HBcAg core antigen.

anti-HBsAg surface antigen IgG1 mAb

032-A-01mg 0,1 mg
EUR 267.5
Description: anti-HBsAg surface antigen IgG1 (monoclonal) Produced against HBsAg purified from human sera pool.

anti-HBsAg surface antigen IgG1 mAb

032-A-1000ug 1000 ug
EUR 1282.5
Description: anti-HBsAg surface antigen IgG1 (monoclonal) Produced against HBsAg purified from human sera pool.

anti-B human blood antigen IgM

134-A-01mg 0,1 mg
EUR 267.5
Description: anti-B human blood antigen IgM

anti-B human blood antigen IgM

134-A-1000ug 1000 ug
EUR 1282.5
Description: anti-B human blood antigen IgM

anti-AB human blood antigen IgM

135-A-01mg 0,1 mg
EUR 267.5
Description: anti-AB human blood antigen IgM

anti-AB human blood antigen IgM

135-A-1000ug 1000 ug
EUR 1282.5
Description: anti-AB human blood antigen IgM

anti-M human blood antigen IgM

144-A-01mg 0,1 mg
EUR 267.5
Description: anti-M human blood antigen IgM

anti-M human blood antigen IgM

144-A-1000ug 1000 ug
EUR 1282.5
Description: anti-M human blood antigen IgM

Blood Antigen ig2b: Anti-N Human

145-A-01mg 0,1 mg
EUR 267.5
Description: anti-N human blood antigen Ig2b

Blood Antigen ig2b: Anti-N Human

145-A-1000ug 1000 ug
EUR 1282.5
Description: anti-N human blood antigen Ig2b

Anti-Proximal Nephrogenic Renal Antigen antibody

STJ16100515 100 µg
EUR 354

Anti-Endothelial Internalizing Surface Antigen antibody

STJ16100681 1 mL
EUR 391

Anti-Carcinoma Associated antigen MAM6 antibody

STJ16100874 1 mL
EUR 271

Anti-Factor VIII-R Antigen antibody

STJ16101324 1 mL
EUR 435

Anti-Factor VIII-R Antigen antibody

STJ16101460 1 mL
EUR 435

Anti-Proliferating Cell Nuclear Antigen antibody

STJ190086 200 µl
EUR 197
Description: Unconjugated Mouse monoclonal to Proliferating Cell Nuclear Antigen (PCNA) (3F2)

Anti-Retinal S antigen/SAG Antibody

A03775 100ug/vial
EUR 294

Anti-Melanoma-associated antigen D1 Antibody

A05037 100ul
EUR 397
Description: Rabbit Polyclonal Melanoma-associated antigen D1 Antibody. Validated in WB and tested in Human, Mouse, Rat.

Anti-Stromal antigen 2 / STAG2 antibody

STJ72075 100 µg
EUR 359

Anti-TF Antigen Peptide P30-1

H-5988.0001 1.0mg
EUR 236
Description: Sum Formula: C94H130N26O19; CAS# [573664-50-3] net

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