Integrating Prostate-specific Antigen Kinetics into Contemporary
Integrating Prostate-specific Antigen Kinetics into Up to date Predictive Nomograms of Salvage Radiotherapy After Radical Prostatectomy
Background: Salvage radiotherapy (SRT) is a longtime remedy for males with biochemical recurrence following radical prostatectomy (RP). There are a number of danger elements related to antagonistic outcomes; nevertheless, the worth of postoperative prostate-specific antigen (PSA) kinetics is much less clear within the ultrasensitive PSA period.
Goal: To characterize the impression of PSA kinetics on outcomes following SRT and generate nomograms to help in figuring out sufferers with an elevated danger of antagonistic scientific outcomes.
Design, setting, and individuals: A multi-institutional evaluation was carried out of 1005 sufferers with prostate most cancers handled with SRT after RP, with a median follow-up of 5 years.
Final result measurements and statistical evaluation: Variables examined embrace instant postoperative PSA, postoperative PSA doubling time (DT), and pre-SRT PSA, along with beforehand recognized predictive elements. Multivariable survival analyses have been accomplished utilizing High quality-Grey competing danger regression. Charges of biochemical failure (BF), distant metastasis (DM), and prostate cancer-specific mortality (PCSM) have been estimated by the cumulative incidence methodology. Nomograms have been generated from multivariable competing danger regression with bootstrap cross-validation.
Outcomes and limitations: Elements related to BF after SRT embrace PSA DT <6 mo, preliminary postoperative PSA ≥0.2 ng/ml, greater pre-SRT PSA, lack of androgen deprivation remedy, a better Gleason rating (GS), detrimental margins, seminal vesicle invasion, lack of pelvic nodal radiation, radiation complete dose <66 Gy, an extended RP to SRT interval, and older age (p < 0.05 for every). Elements related to DM embrace PSA DT <6 mo, pre-SRT PSA, a better GS, and detrimental margins. Elements related to PCSM embrace PSA DT not calculable or <6 mo and a better GS. Nomograms have been generated to estimate the dangers of BF (concordance index [CI] 0.74), DM (CI 0.77), and PCSM (CI 0.77). Limitations embrace retrospective nature, broad remedy eras, institutional variations, and a number of strategies out there for the estimation of PSA DT.
Conclusions: Postoperative PSA kinetics, significantly pre-SRT PSA and PSA DT, are strongly related to antagonistic oncologic outcomes following SRT and ought to be thought-about in administration selections.
Affected person abstract: On this report of males with prostate most cancers who developed a prostate-specific antigen (PSA) recurrence after prostatectomy, we discovered that PSA ranges after surgical procedure and the way shortly a PSA stage doubles considerably impression the possibility of prostate most cancers recurrence after salvage radiation remedy. Based mostly on this data, we created a device to calculate a person’s probability of most cancers recurrence after salvage radiation remedy, and these estimations can be utilized to debate whether or not extra remedy with radiation ought to be thought-about.
 DiscoveryProbe? Stem Cell Compound Library |
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| L1040-.1 | ApexBio | 100 uL/well(10 mM solution) | EUR 4353 |
 Stem Cell MicroRNA Profiling Panel |
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| RA620A-1 | SBI | 10 profiles | EUR 1172 |
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 AssayMax ELISA Kit) Mouse Stem Cell Factor (SCF) AssayMax ELISA Kit |
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| EMS1001-1 | AssayPro | 96 Well Plate | EUR 396 |
) Mouse Nanog Stem Cell Differentiation Reporter (pGreenZeo, plasmid) |
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| SR10031PA-1 | SBI | 10 ug | EUR 1749 |
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) Mouse Nanog Stem Cell Differentiation Reporter (pGreenZeo, pre-packaged) |
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| SR10031VA-1 | SBI | >2 x 10^6 IFUs | EUR 755 |
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 Polyclonal Goat anti-GST α-form |
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| GST-ANTI-1 | Detroit R&D | 50 uL | EUR 280 |
 SCF Stem Cell Factor Human Recombinant Protein |
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| PROTP21583-1 | BosterBio | Regular: 10ug | EUR 317 |
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Description: Stem Cell Factor Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 165 amino acids and having a molecular mass of 18409 Dalton. ;The SCF is purified by proprietary chromatographic techniques. |
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) StemBoost? Neural Stem Cell Reprogramming Cocktail (100X) |
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| S238-1 | Biovision | EUR 185 | |
 SCA-1 Antibody |
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| 47996-100ul | SAB | 100ul | EUR 333 |
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SCA-1 Antibody |
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| 47996-50ul | SAB | 50ul | EUR 239 |
 AssayMax ELISA Kit) Human Stem Cell Factor (SCF) AssayMax ELISA Kit |
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| ES1001-1 | AssayPro | 96 Well Plate | EUR 396 |
 SCA-1 Conjugated Antibody |
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| C47996 | SAB | 100ul | EUR 397 |
) Mouse Prostate stem cell antigen (Psca) |
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| 1-CSB-YP018840MO | Cusabio |
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Description: Recombinant Mouse Prostate stem cell antigen(Psca) expressed in Yeast |
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 Anti-Periphilin 1 Antibody |
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| A06996-1 | BosterBio | 100ul | EUR 397 |
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Description: Rabbit Polyclonal Antibody for Periphilin 1 Antibody (PPHLN1) detection.tested for WB in Human, Mouse. |
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 Anti-Lyl-1 Antibody |
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| A07491-1 | BosterBio | 100ul | EUR 397 |
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Description: Rabbit Polyclonal Lyl-1 Antibody. Validated in IHC and tested in Human, Mouse, Rat. |
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 Anti-GLI-1 Antibody |
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| A07972-1 | BosterBio | 100ul | EUR 397 |
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Description: Rabbit Polyclonal Antibody for GLI-1 Antibody (ACSS1) detection. Tested with WB in Human, Mouse, Rat. |
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 Anti-Cerebellin 1 Antibody |
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| A09176-1 | BosterBio | 100ul | EUR 397 |
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Description: Rabbit Polyclonal Antibody for Cerebellin 1 Antibody (CBLN1) detection. Tested with WB in Human, Mouse, Rat. |
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 Anti-DOC-1 Antibody |
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| A09467-1 | BosterBio | 100ul | EUR 397 |
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Description: Rabbit Polyclonal Antibody for DOC-1 Antibody (CDK2AP1) detection. Tested with WB in Human, Mouse. |
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 Anti-NPDC-1 Antibody |
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| A12846-1 | BosterBio | 100ul | EUR 397 |
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Description: Rabbit Polyclonal Antibody for NPDC-1 Antibody (NPDC1) detection. Tested with WB in Human, Mouse, Rat. |
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 Anti-CNG-1 Antibody |
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| A05494-1 | BosterBio | 100ul | EUR 397 |
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Description: Rabbit Polyclonal Antibody for CNG-1 Antibody (CNGA1) detection. Tested with WB in Human, Mouse, Rat. |
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 Anti-Flk-1 Antibody |
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| A00901-1 | BosterBio | 100ul | EUR 397 |
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Description: Rabbit Polyclonal Antibody for Flk-1 Antibody (KDR) detection.tested for WB in Human, Mouse. |
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 Anti-EDG-1 Antibody |
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| A01502-1 | BosterBio | 100ul | EUR 397 |
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Description: Rabbit Polyclonal Antibody for EDG-1 Antibody (S1PR1) detection.tested for WB in Human, Mouse, Rat. |
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 Anti-ROBO-1 Antibody |
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| A01530-1 | BosterBio | 100ug | EUR 455 |
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Description: Rabbit Polyclonal ROBO-1 Antibody. Validated in IF, IHC, WB and tested in Human, Mouse, Rat. |
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 Anti-Bag-1 Antibody |
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| A02423-1 | BosterBio | 50 ul | EUR 397 |
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Description: Rabbit Polyclonal Bag-1 Antibody. Validated in IP, IHC and tested in Bovine, Canine, Human, Mouse, Rat. |
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 Anti-TUB 1 Antibody |
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| A02917-1 | BosterBio | 100ug/vial | EUR 294 |
 Anti-Dok-1 Antibody |
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| A03039-1 | BosterBio | 100ul | EUR 397 |
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Description: Rabbit Polyclonal Antibody for Dok-1 Antibody (DOK1) detection.tested for WB in Human, Mouse, Rat. |
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 Anti-TFIIIB90-1 Antibody |
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| A03761-1 | BosterBio | 100ul | EUR 397 |
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Description: Rabbit Polyclonal Antibody for TFIIIB90-1 Antibody (BRF1) detection.tested for WB in Human, Mouse. |
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 Anti-Atrophin-1 Antibody |
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| A03828-1 | BosterBio | 100ul | EUR 397 |
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Description: Rabbit Polyclonal Antibody for Atrophin-1 Antibody (ATN1) detection. Tested with WB in Human, Mouse, Rat. |
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 Anti-PARP-1 Antibody |
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| A00122-1 | BosterBio | 100ul | EUR 397 |
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Description: Rabbit Polyclonal PARP-1 Antibody. Validated in ELISA, IP, IF, WB and tested in Human, Mouse. |
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 Anti-Presenilin 1 Antibody |
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| A00138-1 | BosterBio | 100ul | EUR 397 |
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Description: Rabbit Polyclonal Antibody for Presenilin 1 Antibody (PSEN1) detection. Tested with WB, IHC in Human, Mouse, Rat. |
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 Anti-PAI-1 Antibody |
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| A00637-1 | BosterBio | 100ul | EUR 397 |
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Description: Rabbit Polyclonal Antibody for PAI-1 Antibody (SERPINE1) detection.tested for WB in Human, Mouse, Rat. |
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) Anti-HO-1 Monoclonal Antibody (HO-1-2) |
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| M00253-1 | BosterBio | 1mg | EUR 397 |
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Description: Mouse Monoclonal HO-1 Antibody (HO-1-2). Validated in Flow Cytometry, IHC, WB and tested in Human, Mouse, Rat. |
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 Anti-Pyrophosphatase 1/PPA1 Antibody |
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| A07485-1 | BosterBio | 100ug/vial | EUR 334 |
 Anti-TCP-1 eta Antibody |
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| A08169-1 | BosterBio | 100ul | EUR 397 |
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Description: Rabbit Polyclonal Antibody for TCP-1 eta Antibody (CCT7) detection. Tested with WB in Human, Mouse, Rat. |
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 Anti-Relaxin 1/RLN1 Antibody |
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| A08367-1 | BosterBio | 100ug/vial | EUR 334 |
 Anti-TCP-1 zeta Antibody |
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| A09373-1 | BosterBio | 100ul | EUR 397 |
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Description: Rabbit Polyclonal Antibody for TCP-1 zeta Antibody (CCT6A) detection.tested for WB in Human, Mouse, Rat. |
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 Anti-CHST8/Galnac4St 1 Antibody |
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| A10989-1 | BosterBio | 100ul | EUR 397 |
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Description: Rabbit Polyclonal CHST8/Galnac4St 1 Antibody. Validated in WB and tested in Human, Mouse, Rat. |
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 Anti-Musashi 1/Msi1 Antibody |
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| A05052-1 | BosterBio | 100ug/vial | EUR 334 |
 Anti-LOX-1/OLR1 Antibody |
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| A00760-1 | BosterBio | 100ug/vial | EUR 294 |
 Anti-Syndecan-1/SDC1 Antibody |
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| A00991-1 | BosterBio | 100ug/vial | EUR 294 |
 Anti-IRAK-1/IRAK1 Antibody |
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| A01021-1 | BosterBio | 100ug/vial | EUR 334 |
 Anti-Neurexin 1/NRXN1 Antibody |
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| A01490-1 | BosterBio | 100ug/vial | EUR 334 |
 Anti-Hexokinase 1/HK1 Antibody |
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| A01504-1 | BosterBio | 100ug/vial | EUR 334 |
 Anti-Synaptotagmin 1/SYT1 Antibody |
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| A02314-1 | BosterBio | 100ug/vial | EUR 334 |
 Anti-Syntenin-1 Monoclonal Antibody |
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| A02475-1 | BosterBio | 100ul | EUR 397 |
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Description: Mouse Monoclonal Antibody for Syntenin-1 Antibody (SDCBP) detection. Tested with WB in Human, Rat, Dog, Pig. |
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 Anti-Dsg1/Desmoglein 1 Antibody |
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| A02655-1 | BosterBio | 100ul | EUR 397 |
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Description: Rabbit Polyclonal Antibody for Dsg1 Antibody (DSG1) detection.tested for IHC, WB in Human, Mouse, Rat. |
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 Anti-CAF-1 p150 Antibody |
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| A02732-1 | BosterBio | 100ul | EUR 397 |
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Description: Rabbit Polyclonal Antibody for CAF-1 p150 Antibody (CHAF1A) detection. Tested with WB in Human, Mouse. |
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 Anti-Talin 1/TLN1 Antibody |
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| A02859-1 | BosterBio | 100ug/vial | EUR 334 |
 Anti-Islet 1/ISL1 Antibody |
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| A02969-1 | BosterBio | 100ug/vial | EUR 334 |
 Anti-TNF Receptor 1 Antibody |
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| A00294-1 | BosterBio | 200ug | EUR 522 |
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Description: Rabbit Polyclonal TNF Receptor 1 Antibody. Validated in IP, IHC, WB and tested in Human, Mouse, Rat. |
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 Anti-Galectin 1/Lgals1 Antibody |
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| A00470-1 | BosterBio | 100ug/vial | EUR 334 |
 Anti-Angiopoietin 1/ANGPT1 Antibody |
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| PA1333-1 | BosterBio | 100ug/vial | EUR 334 |
 Anti-Presenilin 1 Monoclonal Antibody |
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| M00138-1 | BosterBio | 100ug | EUR 397 |
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Description: Rabbit Monoclonal Presenilin 1 Antibody. Validated in WB and tested in Human, Mouse, Rat. |
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 Anti-Galectin 1 Monoclonal Antibody |
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| M00470-1 | BosterBio | 100ug | EUR 397 |
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Description: Rabbit Monoclonal Galectin 1 Antibody. Validated in IP, IF, WB and tested in Human, Mouse, Rat. |
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 Anti-DJ-1 Monoclonal Antibody |
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| M00757-1 | BosterBio | 100ul | EUR 397 |
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Description: Mouse Monoclonal DJ-1 Antibody. Validated in IHC, WB and tested in Bovine, Human. |
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 Anti-Enolase 1 Monoclonal Antibody |
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| M01250-1 | BosterBio | 100ul | EUR 397 |
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Description: Anti-Enolase 1 Monoclonal Antibody tested in WB, IF, ICC, IHC, reactive to Human, rat, mouse, cow, pig, horse |
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 Anti-Dynamin 1 Monoclonal Antibody |
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| M02536-1 | BosterBio | 100ug | EUR 397 |
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Description: Rabbit Monoclonal Dynamin 1 Antibody. Validated in IF, WB and tested in Human, Mouse, Rat. |
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 Anti-Esrp-1 Monoclonal Antibody |
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| M06068-1 | BosterBio | 100uL | EUR 443 |
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Description: Mouse Monoclonal Esrp-1 Antibody. Validated in WB and tested in Human. |
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 Anti-Galectin 1/LGALS1 Antibody |
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| PB9240-1 | BosterBio | 100ug/vial | EUR 334 |
, 2mg/mL) CF350 Goat Anti-Mouse IgG1 (γ1), 2mg/mL |
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| 20245-1 | Biotium | 50uL | EUR 149 |
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Description: Minimum order quantity: 1 unit of 50uL |
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, 2mg/mL) CF488A Goat Anti-Mouse IgG1 (γ1), 2mg/mL |
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| 20246-1 | Biotium | 50uL | EUR 149 |
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Description: Minimum order quantity: 1 unit of 50uL |
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, 2mg/mL) CF555 Goat Anti-Mouse IgG1 (γ1), 2mg/mL |
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| 20247-1 | Biotium | 50uL | EUR 149 |
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Description: Minimum order quantity: 1 unit of 50uL |
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, 2mg/mL) CF568 Goat Anti-Mouse IgG1 (γ1), 2mg/mL |
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| 20248-1 | Biotium | 50uL | EUR 149 |
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Description: Minimum order quantity: 1 unit of 50uL |
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, 2mg/mL) CF594 Goat Anti-Mouse IgG1 (γ1), 2mg/mL |
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| 20249-1 | Biotium | 50uL | EUR 149 |
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Description: Minimum order quantity: 1 unit of 50uL |
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, 2mg/mL) CF633 Goat Anti-Mouse IgG1 (γ1), 2mg/mL |
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| 20250-1 | Biotium | 50uL | EUR 149 |
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Description: Minimum order quantity: 1 unit of 50uL |
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, 2mg/mL) CF640R Goat Anti-Mouse IgG1 (γ1), 2mg/mL |
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| 20251-1 | Biotium | 50uL | EUR 149 |
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Description: Minimum order quantity: 1 unit of 50uL |
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, 2mg/mL) CF647 Goat Anti-Mouse IgG1 (γ1), 2mg/mL |
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| 20252-1 | Biotium | 50uL | EUR 149 |
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Description: Minimum order quantity: 1 unit of 50uL |
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, 2mg/mL) CF680 Goat Anti-Mouse IgG1 (γ1), 2mg/mL |
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| 20253-1 | Biotium | 50uL | EUR 161 |
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Description: Minimum order quantity: 1 unit of 50uL |
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, 2mg/mL) CF770 Goat Anti-Mouse IgG1 (γ1), 2mg/mL |
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| 20254-1 | Biotium | 50uL | EUR 161 |
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Description: Minimum order quantity: 1 unit of 50uL |
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, 2mg/mL) CF543 Goat Anti-Mouse IgG1 (γ1), 2mg/mL |
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| 20325-1 | Biotium | 50uL | EUR 149 |
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Description: Minimum order quantity: 1 unit of 50uL |
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 Prostate Stem Cell Antigen Antibody |
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| 33476-100ul | SAB | 100ul | EUR 252 |
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Prostate Stem Cell Antigen Antibody |
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| 33476-50ul | SAB | 50ul | EUR 187 |
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Prostate Stem Cell Antigen Antibody |
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| DF8709 | Affbiotech | 200ul | EUR 304 |
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Description: Prostate Stem Cell Antigen Antibody detects endogenous levels of total Prostate Stem Cell Antigen. |
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Prostate Stem Cell Antigen Antibody |
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| ABD8709 | Lifescience Market | 100 ug | EUR 438 |
) Hemokinin 1 (mouse) |
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| B5127-1 | ApexBio | 1 mg | EUR 321 |
 AXMIR-1 RNA oligo anti-miRNA-1-3p with Xmotif |
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| AXMIR-1 | SBI | 10 reactions | EUR 438 |
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 Anti-BOB-1/OBF-1 Rabbit Monoclonal Antibody, Clone#RM378 |
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| M04431-1 | BosterBio | 100uL | EUR 385 |
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Description: Anti-BOB-1/OBF-1 Rabbit Monoclonal Antibody, Clone#RM378 tested in WB, IHC, reactive to Human |
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 Anti-CELSR3/Flamingo Homolog 1 Antibody |
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| A07204-1 | BosterBio | 100ul | EUR 397 |
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Description: Rabbit Polyclonal CELSR3/Flamingo Homolog 1 Antibody. Validated in IF and tested in Human, Mouse, Rat. |
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 Anti-LPCAT2/Acyltransferase Like 1 Antibody |
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| A07471-1 | BosterBio | 100ul | EUR 397 |
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Description: Rabbit Polyclonal LPCAT2/Acyltransferase Like 1 Antibody. Validated in WB and tested in Human, Mouse, Rat. |
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 Anti-Hyaluronan synthase 1/HAS1 Antibody |
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| A04784-1 | BosterBio | 100ug/vial | EUR 334 |
 Anti-Liver Carboxylesterase 1/CES1 Antibody |
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| A01741-1 | BosterBio | 100ug/vial | EUR 334 |
 Anti-EBP50/NHERF-1/SLC9A3R1 Antibody |
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| A02427-1 | BosterBio | 100ug/vial | EUR 334 |
 Anti-IL1R2/Il 1 Rii Antibody |
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| A03106-1 | BosterBio | 1 ml | EUR 397 |
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Description: Rabbit Polyclonal IL1R2/Il 1 Rii Antibody. Validated in IP, WB and tested in Human. |
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 Anti-HIF-1 alpha/HIF1A Antibody |
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| A00013-1 | BosterBio | 100ug/vial | EUR 294 |
 Antibody) Anti-Cleaved-Notch 1 (V1754) Antibody |
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| A00033-1 | BosterBio | 100ul | EUR 397 |
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Description: Rabbit Polyclonal Antibody for Cleaved-Notch 1 (V1754) Antibody (NOTCH1) detection.tested for WB in Human, Mouse, Rat. |
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 Antibody) Anti-HDAC-1 (C-terminus) Antibody |
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| A00256-1 | BosterBio | 100uL | EUR 443 |
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Description: Rabbit Polyclonal HDAC-1 (C-terminus) Antibody. Validated in IF, IHC, WB and tested in Human. |
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 Anti-VEGF Receptor 1/FLT1 Antibody |
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| A00534-1 | BosterBio | 100ug/vial | EUR 294 |
 Anti-Integrin alpha 1/ITGA1 Antibody |
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| PA1045-1 | BosterBio | 100ug/vial | EUR 334 |
/CASP1 Antibody) Anti-Caspase-1(P20)/CASP1 Antibody |
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| PA1440-1 | BosterBio | 100ug/vial | EUR 294 |
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Anti-VEGF Receptor 1/FLT1 Antibody |
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| PA1966-1 | BosterBio | 100ug/vial | EUR 294 |
 Anti-Sumo 1 Rabbit Monoclonal Antibody |
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| M00631-1 | BosterBio | 100ug/vial | EUR 397 |
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Description: Rabbit Monoclonal Sumo 1 Antibody. Validated in IP, IF, IHC, WB and tested in Human, Mouse, Rat. |
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 Anti-Cytokeratin 1 Rabbit Monoclonal Antibody |
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| M01639-1 | BosterBio | 100ug/vial | EUR 397 |
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Description: Rabbit Monoclonal Cytokeratin 1 Antibody. Validated in WB and tested in Human, Mouse, Rat. |
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) Anti-Mitofusin 1 Antibody (monoclonal, 3H3) |
|||
| M02172-1 | BosterBio | 100ug/vial | EUR 294 |
 Antibody) Anti-Phospho-Beclin-1 (Ser295) Antibody |
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| P00327-1 | BosterBio | 100ul | EUR 398 |
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Description: Rabbit Polyclonal Phospho-Beclin-1 (Ser295) Antibody. Validated in WB and tested in Human. |
|||
 Antibody) Anti-Phospho-Raf-1 (Ser642) Antibody |
|||
| P00446-1 | BosterBio | 100ul | EUR 398 |
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Description: Rabbit Polyclonal Phospho-Raf-1 (Ser642) Antibody. Validated in WB and tested in Human, Rat. |
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 TINAGL1 Human, Tubulointerstitial Nephritis Antigen Like 1 Human Recombinant Protein, Sf9 |
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| PROTQ9GZM7-1 | BosterBio | Regular: 5ug | EUR 317 |
|
Description: TINAGL1 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 455 amino acids (22-467a.a.) and having a molecular mass of 51.2kDa (Molecular size on SDS-PAGE will appear at approximately 50-70kDa). TINAGL1 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques. |
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 Anti-TTF-1 |
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| DB-089-1 | DB Biotech | 1 ml | EUR 750 |
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Description: rabbit monospecific clonal antibodies for ihc-p application; concentrated |
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 (Hematopoietic Stem Cell Marker); Clone 3D3 (Concentrate)) Podocalyxin (PODXL) (Hematopoietic Stem Cell Marker); Clone 3D3 (Concentrate) |
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| RA0264-C.1 | ScyTek Laboratories | 0.1 ml | EUR 125 |
Proposed Framework for Contemplating SARS-CoV-2 Antigen Testing of Unexposed Asymptomatic Staff in Chosen Workplaces
asymptomatic staff in chosen workplaces.
Strategies: This can be a commentary based mostly on established occupational security and well being rules, revealed articles, and different pertinent literature, together with non-peer-reviewed preprints in medrixiv.org previous to April 16, 2021.
Outcomes: Not relevant to this commentary/viewpoint article.
Conclusion: Antigen testing is a quickly evolving and helpful public well being device that can be utilized to information measures to cut back unfold of SARS-CoV-2 in the neighborhood and in chosen workplaces. This commentary supplies a proposed framework for occupational security and well being practitioners and employers for contemplating antigen testing as a way to display asymptomatic staff in chosen non-healthcare settings. When utilized selectively, antigen testing could be a helpful, efficient a part of a complete office program for COVID-19 prevention and management.
Affiliation of single-nucleotide polymorphisms in tumour necrosis issue and human leukocyte antigens genes with sort 1 diabetes
Kind 1 diabetes (T1D) is an autoimmune illness characterised by progressive destruction of insulin-producing pancreatic beta cells. This multifactorial illness has a sturdy genetic part related to the human leukocyte antigens (HLA) and non-HLA areas. On this research, we in contrast frequencies of HLA-DRB1 alleles and single-nucleotide polymorphisms (SNPs) related the genes coding for: toll-like receptors (TLRs), tumour necrosis issue (TNF), interleukin-1 (IL-1), interleukin-1 receptor sort 1 (IL-1R1), interleukin-1 receptor antagonist (IL-1RN), interleukin-2 (IL-2) and interleukin-12B (IL-12B), between T1D sufferers and wholesome controls.
The intention was to establish frequency variations and linkage between these genetic markers in T1D sufferers and wholesome controls. Twelve SNPs have been investigated as follows: rs16944 (IL-1B), rs1143634 (IL-1B), rs1800587 (IL-1A), rs2069762 (IL-2), rs3212227 (IL-12B), rs2234650 (IL-1R1), rs315952 (IL-1RN), rs3804099 (TLR2), rs4986790 (TLR4), rs4986791 (TLR4), rs1800629 (TNF) and rs361525 (TNF). TaqMan genotype assay methodology was used for SNPs genotyping. HLA-DRB1* genes have been typed by Sequence Particular Oligonucleotide Probe (SSOP). SPSS and SNPStats packages have been used for the statistical evaluation. Vital variations between T1D and management teams have been discovered for the dominant mannequin of rs361525 and rs1800629A:rs361525G genotypes for TNF.
Elevated frequencies of DRB1*03 and DRB1*04 and decreased frequencies of DRB1*07, DRB1*11 and DRB1*13 and DRB1*15 have been noticed in T1D sufferers in contrast with controls. Nonetheless, the genotype, DRB1*07 with rs1800629A/G was related to T1D. Now we have confirmed that DRB1*03 and DRB1*04 are related to elevated danger and DRB1*07, DRB1*11 and DRB1*13 and DRB1*15 with decreased danger of T1D. Additionally, the dominant mannequin of rs361525A, and the rs1800629G:361525A genotype have been related to elevated danger. The simultaneous presence of DRB1*07 and rs1800629A/G genotypes in 23 out of 27 DRB1*07 optimistic T1D sufferers implied that islet cell peptide processing could have been biased in direction of autoimmunity by upregulation of TNF related intronic SNPs.
Are chimeric antigen receptor T cells (CAR-T cells) the long run in immunotherapy for autoimmune illnesses?
Goal: CAR-T cell remedy has revolutionized the remedy of oncological illnesses, and potential makes use of in autoimmune illnesses have lately been described. The assessment goals to combine the out there knowledge on remedy with CAR-T cells, emphasizing autoimmune illnesses, to find out therapeutic advances and their doable future scientific applicability in autoimmunity.
Supplies and strategies: A search was carried out in PubMed with the key phrases “Chimeric Antigen Receptor” and “CART cell”. The paperwork of curiosity have been chosen, and a vital assessment of the data was carried out.
Outcomes: Within the remedy of autoimmune illnesses, in preclinical fashions, three totally different mobile methods have been used, which embrace Chimeric antigen receptor T cells, Chimeric autoantibody receptor T cells, and Chimeric antigen receptor in regulatory T lymphocytes. All three varieties of remedy have been efficient. The potential antagonistic results inside them, cytokine launch syndrome, mobile toxicity and neurotoxicity should at all times be saved in thoughts.
Conclusions: Though data in people will not be but out there, preclinical fashions of CAR-T cells within the remedy of autoimmune illnesses present promising outcomes, in order that sooner or later, they might develop into a helpful and efficient remedy within the remedy of those pathologies.
 Polyclonal Goat anti-GST p-form |
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| GST-ANTI-3 | Detroit R&D | 50 uL | EUR 280 |
 anti-FAS antigen |
|||
| 519-A-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: anti-FAS antigen |
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anti-FAS antigen |
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| 519-A-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: anti-FAS antigen |
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 anti-CD300 antigen |
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| YF-PA17583 | Abfrontier | 50 ul | EUR 363 |
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Description: Mouse polyclonal to CD300 antigen |
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anti-CD300 antigen |
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| YF-PA17584 | Abfrontier | 50 ug | EUR 363 |
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Description: Mouse polyclonal to CD300 antigen |
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anti-CD300 antigen |
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| YF-PA17585 | Abfrontier | 50 ul | EUR 363 |
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Description: Mouse polyclonal to CD300 antigen |
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 Mouse Anti-EBV Nuclear Antigen Monoclonal Antibody |
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| DMAB3332-05mg | Creative Diagnostics | 0.5 mg | EUR 969 |
Mouse Anti-EBV Nuclear Antigen Monoclonal Antibody |
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| DMAB3332-1mg | Creative Diagnostics | 1 mg | EUR 1469 |
 Mouse Anti Melanoma associated antigen ELISA kit |
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| E03M0220-192T | B-Gene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Mouse Anti Melanoma associated antigen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Anti Melanoma associated antigen ELISA kit |
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| E03M0220-48 | B-Gene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Mouse Anti Melanoma associated antigen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Anti Melanoma associated antigen ELISA kit |
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| E03M0220-96 | B-Gene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Mouse Anti Melanoma associated antigen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 Mouse Anti soluble liver antigen ELISA kit |
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| E03S0263-192T | B-Gene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Mouse Anti soluble liver antigen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Anti soluble liver antigen ELISA kit |
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| E03S0263-48 | B-Gene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Mouse Anti soluble liver antigen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Anti soluble liver antigen ELISA kit |
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| E03S0263-96 | B-Gene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Mouse Anti soluble liver antigen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 Anti-Ku80 Antigen Purified |
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| 11-496-C025 | ExBio | 0.025 mg | EUR 108 |
Anti-Ku80 Antigen Purified |
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| 11-496-C100 | ExBio | 0.1 mg | EUR 177 |
 Anti-Carcinoembryonic Antigen antibody |
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| STJ16100878 | St John's Laboratory | 1 mL | EUR 668 |
 Anti-Nucleolar Antigen antibody |
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| STJ16101002 | St John's Laboratory | 100 µg | EUR 354 |
 Anti-Liver Antigen antibody |
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| STJ16101073 | St John's Laboratory | 100 µg | EUR 354 |
Anti-Liver Antigen antibody |
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| STJ16101074 | St John's Laboratory | 100 µg | EUR 354 |
Anti-Carcinoembryonic Antigen antibody |
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| STJ96963 | St John's Laboratory | 200 µl | EUR 197 |
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Description: Carcinoembryonic antigen is a protein encoded by the CEACAM5 gene which is approximately 76,7 kDa. Carcinoembryonic antigen is localised to the cell membrane. It is involved in the metabolism of proteins and hematopoietic stem cell differentiation pathways and lineage-specific markers. It is a cell surface glycoprotein that plays a role in cell adhesion and in intracellular signalling. It may also regulate differentiation, apoptosis, and cell polarity and is used as a clinical biomarker for gastrointestinal cancers. Carcinoembryonic antigen is expressed in the intestine, liver, saliva, stomach and lung. Mutations in the CEACAM5 gene may be involved in urachal cancer. STJ96963 was developed from clone 10E1 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This primary antibody detects endogenous Carcinoembryonic antigen proteins. |
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 anti-Prostate Specific Antigen |
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| YF-PA10281 | Abfrontier | 50 ug | EUR 363 |
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Description: Mouse polyclonal to Prostate Specific Antigen |
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anti-Prostate Specific Antigen |
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| YF-PA10282 | Abfrontier | 100 ug | EUR 403 |
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Description: Rabbit polyclonal to Prostate Specific Antigen |
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 Mouse Anti-Bacillus anthracis Protective Antigen Monoclonal Antibody |
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| DMAB3024 | Creative Diagnostics | 1 mg | EUR 903 |
Mouse Anti-Bacillus anthracis Protective Antigen Monoclonal Antibody |
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| DMAB3028 | Creative Diagnostics | 1 mg | EUR 955 |
Mouse Anti-Bacillus anthracis Protective Antigen Monoclonal Antibody |
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| DMAB3029 | Creative Diagnostics | 1 mg | EUR 955 |
Mouse Anti-Bacillus anthracis Protective Antigen Monoclonal Antibody |
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| DMAB3031 | Creative Diagnostics | 1 mg | EUR 903 |
 Mouse Anti-Bacillus anthracis Spore Antigen Monoclonal Antibody |
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| DMAB3033-05mg | Creative Diagnostics | 0.5 mg | EUR 969 |
Mouse Anti-Bacillus anthracis Spore Antigen Monoclonal Antibody |
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| DMAB3033-1mg | Creative Diagnostics | 1 mg | EUR 1469 |
Mouse Anti-Bacillus anthracis Spore Antigen Monoclonal Antibody |
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| DMAB3034-05mg | Creative Diagnostics | 0.5 mg | EUR 969 |
Mouse Anti-Bacillus anthracis Spore Antigen Monoclonal Antibody |
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| DMAB3034-1mg | Creative Diagnostics | 1 mg | EUR 1469 |
 Mouse Anti-Hepatitis B Core Antigen Monoclonal Antibody |
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| DMAB3498 | Creative Diagnostics | 1 mg | EUR 833 |
 Mouse Anti-Hepatitis B Surface Antigen Monoclonal Antibody |
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| DMAB3525 | Creative Diagnostics | 1 mg | EUR 781 |
Mouse Anti-Hepatitis B Surface Antigen Monoclonal Antibody |
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| DMAB3531 | Creative Diagnostics | 1 mg | EUR 741 |
Mouse Anti-Hepatitis B Surface Antigen Monoclonal Antibody |
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| DMAB3532 | Creative Diagnostics | 1 mg | EUR 741 |
Mouse Anti-Hepatitis B Surface Antigen Monoclonal Antibody |
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| DMAB3536-05mg | Creative Diagnostics | 0.5 mg | EUR 969 |
Mouse Anti-Hepatitis B Surface Antigen Monoclonal Antibody |
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| DMAB3536-1mg | Creative Diagnostics | 1 mg | EUR 1469 |
Mouse Anti-Hepatitis B Surface Antigen Monoclonal Antibody |
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| DMAB3537-05mg | Creative Diagnostics | 0.5 mg | EUR 969 |
Mouse Anti-Hepatitis B Surface Antigen Monoclonal Antibody |
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| DMAB3537-1mg | Creative Diagnostics | 1 mg | EUR 1469 |
Mouse Anti-Hepatitis B Surface Antigen Monoclonal Antibody |
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| DMAB3540 | Creative Diagnostics | 1 mg | EUR 741 |
Mouse Anti-Hepatitis B Surface Antigen Monoclonal Antibody |
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| DMAB3543 | Creative Diagnostics | 1 mg | EUR 741 |
Mouse Anti-Hepatitis B Surface Antigen Monoclonal Antibody |
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| DMAB3545 | Creative Diagnostics | 1 mg | EUR 632 |
Mouse Anti-Hepatitis B Surface Antigen Monoclonal Antibody |
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| DMAB3546 | Creative Diagnostics | 1 mg | EUR 632 |
 Mouse Anti Borrelia Burgdorferi Flagellar Antigen Monoclonal Antibody |
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| DMABT-51105MB | Creative Diagnostics | 0.2 mg | EUR 715 |
 Mouse Anti Chlamydia Trachomatis 30Kda Antigen Monoclonal Antibody |
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| DMABT-51152MC | Creative Diagnostics | 0.2 mg | EUR 663 |
 Mouse Anti Hepatitis A Surface Antigen Monoclonal Antibody |
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| DMABT-51310MH | Creative Diagnostics | 0.2 mg | EUR 741 |
 Mouse Anti Hepatitis B Core Antigen Monoclonal Antibody |
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| DMABT-51311MH | Creative Diagnostics | 0.2 mg | EUR 767 |
Mouse Anti Hepatitis B Core Antigen Monoclonal Antibody |
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| DMABT-51312MH | Creative Diagnostics | 0.2 mg | EUR 710 |
Mouse Anti Hepatitis B Core Antigen Monoclonal Antibody |
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| DMABT-51314MH | Creative Diagnostics | 0.2 mg | EUR 580 |
Mouse Anti Hepatitis B Core Antigen Monoclonal Antibody |
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| DMABT-51315MH | Creative Diagnostics | 0.2 mg | EUR 710 |
Mouse Anti Hepatitis B Core Antigen Monoclonal Antibody |
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| DMABT-51316MH | Creative Diagnostics | 0.2 mg | EUR 663 |
Mouse Anti Hepatitis B Core Antigen Monoclonal Antibody |
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| DMABT-51317MH | Creative Diagnostics | 0.2 mg | EUR 710 |
 Mouse Anti Hepatitis B E Antigen Monoclonal Antibody |
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| DMABT-51319MH | Creative Diagnostics | 0.2 mg | EUR 767 |
 Mouse Anti Hepatitis B Surface Antigen Monoclonal Antibody |
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| DMABT-51323MH | Creative Diagnostics | 0.2 mg | EUR 580 |
Mouse Anti Hepatitis B Surface Antigen Monoclonal Antibody |
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| DMABT-51324MH | Creative Diagnostics | 0.1 ml | EUR 445 |
Mouse Anti Hepatitis B Surface Antigen Monoclonal Antibody |
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| DMABT-51325MH | Creative Diagnostics | 1 ml | EUR 819 |
Mouse Anti Hepatitis B Surface Antigen Monoclonal Antibody |
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| DMABT-51326MH | Creative Diagnostics | 1 ml | EUR 445 |
Mouse Anti Hepatitis B Surface Antigen Monoclonal Antibody |
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| DMABT-51327MH | Creative Diagnostics | 6 ml | EUR 715 |
Mouse Anti Hepatitis B Surface Antigen Monoclonal Antibody |
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| DMABT-51328MH | Creative Diagnostics | 0.1 mg | EUR 741 |
 Mouse Anti Hepatitis B X Antigen Monoclonal Antibody |
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| DMABT-51330MH | Creative Diagnostics | 0.25 mg | EUR 725 |
 Mouse Anti Hepatitis C Core Antigen Monoclonal Antibody |
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| DMABT-51332MH | Creative Diagnostics | 0.1 mg | EUR 767 |
 Mouse Anti Hepatitis C E1 Antigen Monoclonal Antibody |
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| DMABT-51333MH | Creative Diagnostics | 0.1 mg | EUR 944 |
 Mouse Anti Hepatitis C E2 Antigen Monoclonal Antibody |
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| DMABT-51334MH | Creative Diagnostics | 0.1 mg | EUR 944 |
 Mouse Anti Influenza A H5 Antigen Monoclonal Antibody |
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| DMABT-51386MI | Creative Diagnostics | 0.2 mg | EUR 663 |
Mouse Anti Influenza A H5 Antigen Monoclonal Antibody |
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| DMABT-51388MI | Creative Diagnostics | 0.2 mg | EUR 741 |
 Mouse Anti Mycobacterium Tuberculosis 16Kda Antigen Monoclonal Antibody |
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| DMABT-51441MM | Creative Diagnostics | 0.1 mg | EUR 892 |
Mouse Anti Mycobacterium Tuberculosis 16Kda Antigen Monoclonal Antibody |
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| DMABT-51442MM | Creative Diagnostics | 0.1 mg | EUR 892 |
 Mouse Anti Mycobacterium Tuberculosis 38Kda Antigen Monoclonal Antibody |
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| DMABT-51444MM | Creative Diagnostics | 0.2 mg | EUR 767 |
Mouse Anti Mycobacterium Tuberculosis 38Kda Antigen Monoclonal Antibody |
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| DMABT-51446MM | Creative Diagnostics | 0.2 mg | EUR 767 |
Mouse Anti Mycobacterium Tuberculosis 38Kda Antigen Monoclonal Antibody |
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| DMABT-51448MM | Creative Diagnostics | 0.2 mg | EUR 767 |
 Mouse Anti Yersinia Pestis V Antigen Monoclonal Antibody |
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| DMABT-51632MY | Creative Diagnostics | 0.2 mg | EUR 767 |
Mouse Anti Yersinia Pestis V Antigen Monoclonal Antibody |
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| DMABT-51634MY | Creative Diagnostics | 0.2 mg | EUR 767 |
 Mouse anti- extractable nuclear antigen antibody ELISA Kit |
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| ELA-E1124m | Lifescience Market | 96 Tests | EUR 865 |
 Rat Anti Mouse F4/80 Antigen Monoclonal Antibody |
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| CABT-47632RM | Creative Diagnostics | 0.1 mg | EUR 663 |
 Anti-Flavivirus group antigen Antibody |
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| A1146-200 | Biovision | EUR 697 | |
Anti-Flavivirus group antigen Antibody |
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| A1147-200 | Biovision | EUR 697 | |
 anti-RhoD human antigen IgG1 |
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| 131-A-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: anti-RhoD human antigen IgG1 |
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anti-RhoD human antigen IgG1 |
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| 131-A-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: anti-RhoD human antigen IgG1 |
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) anti-Carcinoembryonic Antigen/CEA (10E1) |
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| LF-MA20354 | Abfrontier | 100 ug | EUR 354 |
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Description: Mouse monoclonal to Carcinoembryonic Antigen (CEA) |
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 Anti-HLA-DR antigen antibody |
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| STJ16100045 | St John's Laboratory | 1 mL | EUR 478 |
 Anti-CD95/FAS antigen antibody |
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| STJ16100141 | St John's Laboratory | 100 µg | EUR 354 |
 Anti-Rat CD4-antigen antibody |
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| STJ16100150 | St John's Laboratory | 1 mL | EUR 604 |
 Anti-Myeloid Specific Antigen antibody |
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| STJ16100158 | St John's Laboratory | 100 µg | EUR 389 |
Anti-Myeloid Specific Antigen antibody |
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| STJ16100170 | St John's Laboratory | 100 µg | EUR 389 |
Anti-Myeloid Specific Antigen antibody |
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| STJ16100171 | St John's Laboratory | 100 µg | EUR 389 |
Anti-Myeloid Specific Antigen antibody |
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| STJ16100172 | St John's Laboratory | 100 µg | EUR 389 |
 Anti-Hepatocyte Specific Antigen antibody |
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| STJ16100376 | St John's Laboratory | 1 mL | EUR 795 |
 Anti-Melamona-Associated Antigen antibody |
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| STJ16100389 | St John's Laboratory | 1 mL | EUR 871 |
Anti-Melamona-Associated Antigen antibody |
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| STJ16100390 | St John's Laboratory | 1 mL | EUR 838 |
 Anti-Melanoma Discr. Antigen antibody |
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| STJ16100730 | St John's Laboratory | 1 mL | EUR 290 |
Anti-Melanoma Discr. Antigen antibody |
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| STJ16100731 | St John's Laboratory | 1 mL | EUR 290 |
 Anti-Melanoma Associated Antigen antibody |
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| STJ16100732 | St John's Laboratory | 1 mL | EUR 253 |
Anti-Melanoma Associated Antigen antibody |
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| STJ16100733 | St John's Laboratory | 1 mL | EUR 271 |
Anti-Melanoma Associated Antigen antibody |
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| STJ16100734 | St John's Laboratory | 1 mL | EUR 271 |
Anti-Melanoma Associated Antigen antibody |
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| STJ16100735 | St John's Laboratory | 1 mL | EUR 271 |
 Anti-Ovarium Carcinoma Antigen antibody |
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| STJ16100873 | St John's Laboratory | 1 mL | EUR 290 |
 Anti-Leukocyte Common Antigen antibody |
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| STJ16100941 | St John's Laboratory | 1 mL | EUR 481 |
